CAJ | 학술논문

目的探讨慢性咳嗽患者支气管激发试验前后小气道功能、气道阻力及胸外气道反应的状况.方法 68例慢性咳嗽患者进行组胺支气管激发试验,观察FEV1、呼气中期流速(MEF50)及吸气中期流速(MIF50)的变化,并应用脉冲振荡技术测定激发前后患者气道阻力.结果支气管激发试验阳性率52％,激发阳性患者激发前MEF50,R0与阴性组患者差异有统计学意义.MEF50激发后/激发前比值(MEF50％)与FEV1激发后/激发前比值(FEV1％)呈正相关,与R0激发前后差值(R0-d)呈负相关.13例患者呈现胸外气道高反应(占总例数20％),其中6例为单独存在胸外气道高反应,7例患者合并支气管气道高反应.结论观察慢性咳嗽患者小气道功能变化,有利于对哮喘的及早诊治,有利于遏制小气道不可逆损害发展为COPD的危险.激发试验时联合观察支气管气道反应和胸外气道反应,可为临床诊断提供线索.
목적 탐토만성해수환자지기관격발시험전후소기도공능、기도조력급흉외기도반응적상황.방법 68례만성해수환자진행조알지기관격발시험,관찰FEV1、호기중기류속(MEF50)급흡기중기류속(MIF50)적변화,병응용맥충진탕기술측정격발전후환자기도조력.결과 지기관격발시험양성솔52％,격발양성환자격발전MEF50,R0여음성조환자차이유통계학의의.MEF50격발후/격발전비치(MEF50％)여FEV1격발후/격발전비치(FEV1％)정정상관,여R0격발전후차치(R0-d)정부상관.13례환자정현흉외기도고반응(점총례수20％),기중6례위단독존재흉외기도고반응,7례환자합병지기관기도고반응.결론 관찰만성해수환자소기도공능변화,유리우대효천적급조진치,유리우알제소기도불가역손해발전위COPD적위험.격발시험시연합관찰지기관기도반응화흉외기도반응,가위림상진단제공선색.
Objective To study the bronchial provocation tests before and after the small airway function in patients with chronic cough,airway resistance,and the status of the extrathoracic airway reaction.Methods Sixty-eight patients with chronic cough were histamine bronchial provocation tests,observation FEV1,mid expiratory flow rate (MEF50) the change of the mid and suction flow rate (MIF50),and applies the patients before and after the forced oscillation technique determination inspire airway resistance.Results Bronchial provocation tests positive rate 52％,arouse positive patients before MEF50,R0 patients with negative group difference was statistically significant.MEF50 excitation after/before ratio (MEF50 ％) and FEV1,stimulate after/before ratio (FEV1 ％) were positively correlated,and R0 stimulates the difference before and after the negative correlation (R0 d).Thirteen patients present external chest high reaction (accounts for 20％ of total cases),among them 6 cases to exist alone external chest high response,7 cases of patients with airway hyperresponsiveness bronchial merger.Conclusions To observe change of small airway function in patients with chronic cough,is helpful to early diagnosis and treatment of asthma.Proocation tests joint observation of bronchial airway responses and extrathoracic airway reaction,can provide clues for clinical diagnosis.