国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
5期
329-332
,共4页
沈续瑞%陈澄%周娜娜%黄建安%张秀琴
瀋續瑞%陳澄%週娜娜%黃建安%張秀琴
침속서%진징%주나나%황건안%장수금
咳嗽变异性哮喘%呼出气一氧化氮%激发试验%受试者工作特征曲线
咳嗽變異性哮喘%呼齣氣一氧化氮%激髮試驗%受試者工作特徵麯線
해수변이성효천%호출기일양화담%격발시험%수시자공작특정곡선
Cough variant asthma%Fractional exhaled nitric oxide%Bronchial provocation tests%Receiver operating characteristic curve
目的 评价呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)在检测诊断咳嗽变异性哮喘(cough variant asthma,CVA)方面的准确性及最佳界值.方法 收集2012年10月至2013年10月在苏州大学附属第一医院门诊因慢性咳嗽就诊的172例患者,其中80例最终被诊断为CVA患者,92例为非CVA患者,分为CVA组和非CVA组.所有患者均使用Astrograph气道反应测定仪和FeNO测试仪分别进行激发试验及FeNO浓度检测.根据不同的FeNO值对应的敏感度及特异度绘制受试者工作特征曲线(ROC曲线),评估FeNO诊断CVA的准确性并得出最佳界值.结果 CVA组FeNO值(41.04±18.41)明显高于非CVA组(23.60±16.58)(P＜0.01).ROC曲线下面积是0.830(95％CI:0.767～0.893),FeNO诊断CVA的最佳界值为33 ppb,以33 ppb为诊断CVA的敏感度为73.4％,特异度为81.0％,阳性预测值为77.9％,阴性预测值为78.9％,准确度为78.5％.结论 FeNO在诊断CVA方面具有较高的敏感度和特异度,可作为CVA的辅助诊断手段.
目的 評價呼齣氣一氧化氮(fractional exhaled nitric oxide,FeNO)在檢測診斷咳嗽變異性哮喘(cough variant asthma,CVA)方麵的準確性及最佳界值.方法 收集2012年10月至2013年10月在囌州大學附屬第一醫院門診因慢性咳嗽就診的172例患者,其中80例最終被診斷為CVA患者,92例為非CVA患者,分為CVA組和非CVA組.所有患者均使用Astrograph氣道反應測定儀和FeNO測試儀分彆進行激髮試驗及FeNO濃度檢測.根據不同的FeNO值對應的敏感度及特異度繪製受試者工作特徵麯線(ROC麯線),評估FeNO診斷CVA的準確性併得齣最佳界值.結果 CVA組FeNO值(41.04±18.41)明顯高于非CVA組(23.60±16.58)(P＜0.01).ROC麯線下麵積是0.830(95％CI:0.767～0.893),FeNO診斷CVA的最佳界值為33 ppb,以33 ppb為診斷CVA的敏感度為73.4％,特異度為81.0％,暘性預測值為77.9％,陰性預測值為78.9％,準確度為78.5％.結論 FeNO在診斷CVA方麵具有較高的敏感度和特異度,可作為CVA的輔助診斷手段.
목적 평개호출기일양화담(fractional exhaled nitric oxide,FeNO)재검측진단해수변이성효천(cough variant asthma,CVA)방면적준학성급최가계치.방법 수집2012년10월지2013년10월재소주대학부속제일의원문진인만성해수취진적172례환자,기중80례최종피진단위CVA환자,92례위비CVA환자,분위CVA조화비CVA조.소유환자균사용Astrograph기도반응측정의화FeNO측시의분별진행격발시험급FeNO농도검측.근거불동적FeNO치대응적민감도급특이도회제수시자공작특정곡선(ROC곡선),평고FeNO진단CVA적준학성병득출최가계치.결과 CVA조FeNO치(41.04±18.41)명현고우비CVA조(23.60±16.58)(P＜0.01).ROC곡선하면적시0.830(95％CI:0.767～0.893),FeNO진단CVA적최가계치위33 ppb,이33 ppb위진단CVA적민감도위73.4％,특이도위81.0％,양성예측치위77.9％,음성예측치위78.9％,준학도위78.5％.결론 FeNO재진단CVA방면구유교고적민감도화특이도,가작위CVA적보조진단수단.
Objective Evaluate the accuracy of fractional exhaled nitric oxide (FeNO) determination for the diagnosis of cough variant asthma (CVA) and determine the optimal cut point.Methods Collected 172 cases of chronic cough patients from October 2012 to October 2013 in the First Affiliated Hespital of Soochow University Hospital.Eighty of them were diagnosed with CVA patients and the other 92 were non-CVA,divided into the CVA group and the non-CVA.Astrograph Airway Responsiveness Analyzer and FeNO Tester were used to conduct the excitation experiment and FeNO concentration detection.Based on different FeNO cut point corresponding to specified degree of sensitivity and specificity,the ROC curve was plotted to assess the accuracy of FeNO CVA diagnosis and its optimum cut point.Results FeNO value of CVA group [(41.04± 18.41) ppb] was significantly higher than the non-CVA group [(23.60± 16.58) ppb],and P ＜0.01.Area under the ROC curve was 0.830 (CI:0.767～0.893),the optimal cut point of FeNO used to diagnose CVA is at 33 ppb,by which the value of sensitivity was 73.4 ％ and specificity 81.0 ％,positive predictive value 77.9 ％,negative predictive value 78.9％,accuracy 78.5％.Conclusions FeNO used in the CVA diagnosis shows higher sensitivity and specificity,and it can be used as auxiliary diagnosis of CVA.
