CAJ | 학술논문

目的：：研究A型肉毒毒素(botulinum toxin type A,BTX-A)对神经病理性疼痛模型大鼠P物质(substance P,SP)含量的影响。方法：5%福尔马林50μL皮下注射于大鼠额区及颞区,建立疼痛模型。 BTX-A组局部皮下注射10 U/kg BTX-A,同时设立生理盐水组及空白对照组,放射免疫法测定SP 含量。结果：生理盐水组SP 含量高于空白对照组( P<0．05), BTX-A组低于生理盐水组(P<0．05)。结论： BTX-A可能通过抑制感觉通路神经肽-SP的释放减轻神经病理性疼痛症状。
목적：：연구A형육독독소(botulinum toxin type A,BTX-A)대신경병이성동통모형대서P물질(substance P,SP)함량적영향。방법：5%복이마림50μL피하주사우대서액구급섭구,건립동통모형。 BTX-A조국부피하주사10 U/kg BTX-A,동시설립생리염수조급공백대조조,방사면역법측정SP 함량。결과：생리염수조SP 함량고우공백대조조( P<0．05), BTX-A조저우생리염수조(P<0．05)。결론： BTX-A가능통과억제감각통로신경태-SP적석방감경신경병이성동통증상。
Objective:To detect the change of substance P in neuropathic pain rats injected subcutaneously by botulinum toxin type A. Methods:Besides control group,neuropathic pain rats triggered by 5 % formalin subcutaneously injected into frontal and tem-poral areas,then they had been respectively treated with 0. 9 % NaCl (n=10)and 10 U/kg BTX-A (n=10) for 6 days. All of groups were detected the content of substance P(SP) by radioimmunoassay. Results:The content of SP increased significantly in saline group than that in control group (P<0. 05),but decreased significantly in BTX-A groups than in saline group(P<0. 05). Conclusion:BTX-A could inhibit SP releasing from sensory pathways to relieve the symptoms of neuropathic pain.