CAJ | 학술논문

目的：：探讨前列腺切除术后P63阳性基底细胞在前列腺部尿道上皮修复过程中的作用。方法：15只老年家犬行前列腺增生切除术，术后第3、7、14天取材行HE染色和免疫组织化学染色分别观察前列腺部尿道上皮修复过程和P63蛋白表达水平。结果：术后3 d手术创面偶见P63阳性细胞；术后7 d可见片状P63阳性细胞，且这些细胞与残余前列腺组织相连续；术后14 d可见新生尿道上皮基底层细胞阳性表达P63。结论：残余前列腺组织是BPH术后尿道再上皮化的重要组织，而位于基底层的P63阳性细胞可能是这一修复过程的源细胞之一。
목적：：탐토전렬선절제술후P63양성기저세포재전렬선부뇨도상피수복과정중적작용。방법：15지노년가견행전렬선증생절제술，술후제3、7、14천취재행HE염색화면역조직화학염색분별관찰전렬선부뇨도상피수복과정화P63단백표체수평。결과：술후3 d수술창면우견P63양성세포；술후7 d가견편상P63양성세포，차저사세포여잔여전렬선조직상련속；술후14 d가견신생뇨도상피기저층세포양성표체P63。결론：잔여전렬선조직시BPH술후뇨도재상피화적중요조직，이위우기저층적P63양성세포가능시저일수복과정적원세포지일。
Objective:To evaluate the role of P63 postive basal cell in re-epithelialization of prostatic urethra after resection of the prostate) . Methods:15 older male dogs were treated with resection of the prostate. Specimens of the residual wounds were taken at days 3, 7 and 14 postoperatively to evaluate the expression level of P63 and with HE and immunohistochemical staining. Results:P63 positive cells were detected occasionally in the wounds three days after surgery. At days 7, P63 postive cells appeared lamellar distri-bution connecting with remaining prostatic tissue and at days 14, P63 positive expression was observed in basal cells of newborn urothe-lium. Coclusion:The remaining prostatic tissue plays a great role in re-epithelialization of prostatic urethra after TmLRP and P63 pos-tive cells of basal lamina may be one of the origins of cells for the process.