CAJ | 학술논문

目的：探究苦参素联合恩替卡韦治疗乙型肝炎肝硬化的临床疗效，并分析其作用机制。方法75例乙型肝炎肝硬化患者，随机分为对照组37例，观察组38例。对照组采用临床上常规用药恩替卡韦对患者进行治疗；观察组在对照组基础上加苦参素治疗。记录两组患者治疗前后体内的肝纤维化情况，并对记录结果进行统计学的处理分析。结果两组患者经治疗后，体内的肝纤维化程度都有大幅度下降，且治疗结束后，观察组的肝纤维化的水平明显要小于对照组，差异具有统计学意义(P<0.05)。结论采用苦参素联合恩替卡韦来治疗乙型肝炎肝硬化，能有效缓解乙型肝炎肝硬化情况，降低患者体内肝纤维程度，临床疗效显著，应当引起广大医学卫生工作者的重视。
목적：탐구고삼소연합은체잡위치료을형간염간경화적림상료효，병분석기작용궤제。방법75례을형간염간경화환자，수궤분위대조조37례，관찰조38례。대조조채용림상상상규용약은체잡위대환자진행치료；관찰조재대조조기출상가고삼소치료。기록량조환자치료전후체내적간섬유화정황，병대기록결과진행통계학적처리분석。결과량조환자경치료후，체내적간섬유화정도도유대폭도하강，차치료결속후，관찰조적간섬유화적수평명현요소우대조조，차이구유통계학의의(P<0.05)。결론채용고삼소연합은체잡위래치료을형간염간경화，능유효완해을형간염간경화정황，강저환자체내간섬유정도，림상료효현저，응당인기엄대의학위생공작자적중시。
Objective To investigate the clinical effect of oxymatrine combined with entecavir in the treatment of HBV-related hepatocirrhosis, and to analyze its mechanism. Methods A total of 75 patients with HBV-related hepatocirrhosis were randomly divided into control group with 37 cases and observation group with 38 cases. The control group received common clinical treatment by entecavir, and the observation group received additional oxymatrine for treatment. Conditions of hepatic fibrosis in the two groups were recorded before and after treatment for statistical analysis. Results After treatment, both groups had obviously decreased hepatic fibrosis. The observation group had much lower hepatic fibrosis level than the control group, and their difference had statistical significance (P<0.05). Conclusion Combination of oxymatrine and entecavir for treating HBV-related hepatocirrhosis can effectively relieve condition of HBV-related hepatocirrhosis and reduce hepatic fibrosis level. It contains significant clinical effect, and is worthy of wide attention from medical workers.