CAJ | 학술논문

DNA甲基化是一种发生在DNA序列上的甲基化修饰,可以在转录及细胞分裂前后稳定地遗传.近年来研究发现,DNA甲基化能够受到环境因素的影响,而且DNA甲基化又与冠心病发生发展过程有关.本文就DNA甲基化与冠心病生物标记物的关系,DNA甲基化与冠心病主要病因(动脉粥样硬化)的关系以及DNA甲基化与冠心病致病基因的关系进行了系统的综述分析,并讨论了目前冠心病表观遗传学研究存在的问题,最后探讨了进一步的研究方向.
DNA갑기화시일충발생재DNA서렬상적갑기화수식,가이재전록급세포분렬전후은정지유전.근년래연구발현,DNA갑기화능구수도배경인소적영향,이차DNA갑기화우여관심병발생발전과정유관.본문취DNA갑기화여관심병생물표기물적관계,DNA갑기화여관심병주요병인(동맥죽양경화)적관계이급DNA갑기화여관심병치병기인적관계진행료계통적종술분석,병토론료목전관심병표관유전학연구존재적문제,최후탐토료진일보적연구방향.
DNA methylation is a chemical modification with methyl,occurring in the DNA sequence.It can be inherited steadily before or after the transcription and the cell division.Recent studies demonstrated that DNA methylation is mediated by some environmental factors,and it is involved in the pathogenic process of coronary artery disease.This paper systematically reviews the relationships between DNA methylation and the biomarkers of coronary artery disease,the relationships between DNA methylation and the primary etiology of coronary artery disease,i.e.atherosclerosis,and the relationships between DNA methylation and the pathogenic genes of coronary artery disease.In addition,the problems related to the current epigenetic studies for coronary heart disease are also addressed.Finally,directions for future studies to unravel the relationship between DNA methylation and coronary artery disease are discussed.