CAJ | 학술논문

目的研究降钙素原(procalcitonin,PCT)在输尿管结石继发尿脓毒血症中的应用价值.方法 2010年12月至2014年9月68例怀疑尿脓毒血症的单侧输尿管结石患者,行血常规、C反应蛋白(C-reactive protein,CRP)、PCT、尿沉渣、血培养及尿培养.68例患者根据尿脓毒血症诊断标准分为尿脓毒血症组29例和非尿脓毒血症组39例,比较两组患者的年龄、性别、结石部位、结石大小、血白细胞(WBC)计数值、CRP值、PCT值及尿WBC计数值,并对比尿脓毒血症组治疗前后的PCT值.结果尿脓毒血症组患者年龄、结石大小明显大于非尿脓毒血症组,尿脓毒血症组及非尿脓毒血症组第一时间血清PCT水平分别为(19.09±25.15)和(2.09±1.85) μg/L,组间比较差异有统计学意义(P＜0.05).两组血WBC值(×109/L)分别为11.00±3.47及10.27±2.32,CRP值分别为(17.41±15.24)及(15.02±4.94) mg/L,尿WBC值(/HPF)中位数分别为54及47,组间比较差异均无统计学意义(P＞0.05).尿脓毒血症组治疗后PCT值为(1.06±0.56) μg/L,与治疗前比较差异有统计学意义(P＜0.05).结论 PCT在早期诊断尿脓毒血症、评估病情及指导治疗方面具有较高的临床价值.
목적 연구강개소원(procalcitonin,PCT)재수뇨관결석계발뇨농독혈증중적응용개치.방법 2010년12월지2014년9월68례부의뇨농독혈증적단측수뇨관결석환자,행혈상규、C반응단백(C-reactive protein,CRP)、PCT、뇨침사、혈배양급뇨배양.68례환자근거뇨농독혈증진단표준분위뇨농독혈증조29례화비뇨농독혈증조39례,비교량조환자적년령、성별、결석부위、결석대소、혈백세포(WBC)계수치、CRP치、PCT치급뇨WBC계수치,병대비뇨농독혈증조치료전후적PCT치.결과 뇨농독혈증조환자년령、결석대소명현대우비뇨농독혈증조,뇨농독혈증조급비뇨농독혈증조제일시간혈청PCT수평분별위(19.09±25.15)화(2.09±1.85) μg/L,조간비교차이유통계학의의(P＜0.05).량조혈WBC치(×109/L)분별위11.00±3.47급10.27±2.32,CRP치분별위(17.41±15.24)급(15.02±4.94) mg/L,뇨WBC치(/HPF)중위수분별위54급47,조간비교차이균무통계학의의(P＞0.05).뇨농독혈증조치료후PCT치위(1.06±0.56) μg/L,여치료전비교차이유통계학의의(P＜0.05).결론 PCT재조기진단뇨농독혈증、평고병정급지도치료방면구유교고적림상개치.
Objective To investigate the value of procalcitonin (PCT) for urosepsis secondary to ureteral calculus.Methods Samples of 68 ureteral calculi patients who were suspected of urosepsis were obtained for PCT level,C-reactive protein (CRP) level,blood routine examination,urinary sediment,blood culture and urine culture.Sixty-eighy patients were divided into urosepsis group and non-urosepsis group based on the urosepsis diagnostic standard.The age sex,stone location,stone size,blood WBC count,CRP level,PCT level and urine WBC count were compared between the 2 groups.PCT levels before and after treatment were also compared.Results The age,stone size in urosepsis group were significantly higher than those in non-urosepsis group.The PCT levels of patients in urosepsis group and non-urosepsis group were 19.09±25.15 μg/L and 2.09± 1.85 μg/L respectively before treatment,and there was a significant difference between the 2 groups (P＜0.05).The blood WBC counts (× 109/L) of patients in urosepsis group and non-urosepsis group were 11.00± 3.47 and 10.27±2.32 respectively before treatment (P＞0.05).The CRP levels of patients in urosepsis group and non-urosepsis group were 17.41±15.24 mg/L and 15.02±4.94 mg/L respectively before treatment (P＞0.05).The median urine WBC counts (per HPF) of patients in urosepsis group and non-urosepsis group were 54 and 47 respectively before treatment (P＞0.05).The PCT levels of patients in urosepsis group before and after treatment were 19.09 ± 25.15 μg/L and 1.06 ± 0.56 μg/L,and there was a significant difference (P＜0.05).Conclusion PCT has a definite value for early diagnosis of urosepsis,condition assessment and treatment guideline.