CAJ | 학술논문

目的：评价普通干扰素联合利巴韦林治疗慢性丙型肝炎的临床效果。方法皮下给予普通干扰素和口服利巴韦林治疗4周后88例患者产生 rVr，总疗程48周，在治疗结束达到 sVr 后继续观察1~2年内患者的谷丙转氨酶（alt）、总胆红素（tBil）的指标及 HcV-rna 转阴率。结果治疗4周、12周和48周结束治疗后1~2年内患者肝功能指标均正常，HcV-rna 呈阴性。rVr、sVr、nr 率分别为97.7%、97.7%、2.3%。结论普通干扰素联合利巴韦林是治疗慢性丙型肝炎的有效方法，具有良好的临床效果和高耐受性。
목적：평개보통간우소연합리파위림치료만성병형간염적림상효과。방법피하급여보통간우소화구복리파위림치료4주후88례환자산생 rVr，총료정48주，재치료결속체도 sVr 후계속관찰1~2년내환자적곡병전안매（alt）、총담홍소（tBil）적지표급 HcV-rna 전음솔。결과치료4주、12주화48주결속치료후1~2년내환자간공능지표균정상，HcV-rna 정음성。rVr、sVr、nr 솔분별위97.7%、97.7%、2.3%。결론보통간우소연합리파위림시치료만성병형간염적유효방법，구유량호적림상효과화고내수성。
Objective: to evaluate the therapeutic effect of conventional interferon in combination with ribavirin on chronic hepatitis c. Methods: Patients were given conventional interferon subcutaneously in combination with ribavirin orally and 88 patients were obtained rVr. the course of treatment is 12 weeks and follow-up is1-2 years after treatment. the alt、tBil and negative conservation ratio of HcV-rna were observed in different times. Result: the alt、tBil of patients were declined significantly after 4 weeks, 12 weeks follow-up and turned to normal. The ratio of RVR、sVr、nr/ceVr is 97.7%、97.7%、2.3%, respectively. Conclusion: combination of conventional interferon and ribavirin can be used to chronic hepatitis c, and it has a good tolerance and clinical efficacy.