CAJ | 학술논문

目的：观察脂氧素受体激动剂BML-111对野百合碱（MCT）诱导肺动脉高压大鼠的作用及其机制。方法选择SD大鼠24只，随机分为三组：C组、pH组、B组，pH组和B组大鼠行皮下注射野百合碱50μg/g，C组注射等量生理盐水，B组腹腔注射BML-1111mg/（kg·d），连续4周。观察平均肺动脉压力（MPAP）、右心室收缩压（RVSP）、右心室（RV）/[左室（LV）+室间隔（S）]、肺组织白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平的变化。结果 pH组、B组与C组比较，MPAP、RVSP、RV/（LV+S）、肺组织IL-6及TNF-α水平高于C组（P<0.05）；B组与pH组比较，MPAP、RVSP、RV/（LV+S）、肺组织IL-6及TNF-α低于pH组（P<0.05）。结论脂氧素受体激动剂BML-111可减轻野百合碱诱导肺动脉高压大鼠肺动脉压力，其机制可能与减轻肺组织IL-6及TNF-α水平，抑制肺组织炎症有关。
목적：관찰지양소수체격동제BML-111대야백합감（MCT）유도폐동맥고압대서적작용급기궤제。방법선택SD대서24지，수궤분위삼조：C조、pH조、B조，pH조화B조대서행피하주사야백합감50μg/g，C조주사등량생리염수，B조복강주사BML-1111mg/（kg·d），련속4주。관찰평균폐동맥압력（MPAP）、우심실수축압（RVSP）、우심실（RV）/[좌실（LV）+실간격（S）]、폐조직백개소-6（IL-6）화종류배사인자-α（TNF-α）수평적변화。결과 pH조、B조여C조비교，MPAP、RVSP、RV/（LV+S）、폐조직IL-6급TNF-α수평고우C조（P<0.05）；B조여pH조비교，MPAP、RVSP、RV/（LV+S）、폐조직IL-6급TNF-α저우pH조（P<0.05）。결론지양소수체격동제BML-111가감경야백합감유도폐동맥고압대서폐동맥압력，기궤제가능여감경폐조직IL-6급TNF-α수평，억제폐조직염증유관。
Objective To investigate the effect of BML-111 on rats pulmonary arterial hypertension induced by monocrotaline and mechanisms . Methods 24SD rats were randomly allocated into three groups: C group,pH group and B group,Both pH group and B group processed subcutaneous injection of 50μg/g monocrotaline while C group received same volume of saline,B group performed intraperitoneal injection of BML-111 1mg/kg/d from the day immediately as monocrotaline was injected. The observation: MPAP,RVSP,RV/(LV+S),the pulmonary tissue IL-6 and TNF-α. Results The pH group and B group developed higher level of MPAP,RVSP,RV/(LV+S),the pulmonary IL-6 and TNF-αas compared with C group(P<0.05),B group got lower increase of MPAP,RVSP,RV/(LV+S),the pulmonary IL-6 and TNF-αas compared with pH group(P<0.05). Conclusions BML-111 can ameliorate pulmonary arterial hypertension,inhibition of the pulmonary tissue inflammation may be a potential cause.