CAJ | 학술논문

目的：评价4种诊断方法对人获得性免疫缺陷综合征（AIDS）合并结核病（TB）患者的诊断价值。方法将52例人类免疫缺陷病毒（HIV）感染合并TB患者作为观察组，100例未感染HIV的TB患者为对照组，对两组患者进行结核菌素（PPD）试验、痰结核菌培养、结核抗体和γ干扰素释放试验（IGRA）进行诊断。结果对照组患者PPD试验、痰结核菌培养和结核抗体阳性率明显高于观察组患者，差异有统计学意义（P＜0．01）；而IGRA阳性率两组比较，差异无统计学意义（P＞0．05）；观察组IGRA阳性明显高于PPD试验、痰结核菌培养和结核抗体阳性率，均差异有统计学意义（P＜0．01）。抗逆转录病毒治疗观察组患者IGRA阴性发生率明显高于阳性率，差异有统计学意义（P＜0．05）。结论IGRA是诊断HIV感染合并TB的敏感方法，而抗逆转录病毒治疗可能对结果有一定的影响。
목적：평개4충진단방법대인획득성면역결함종합정（AIDS）합병결핵병（TB）환자적진단개치。방법장52례인류면역결함병독（HIV）감염합병TB환자작위관찰조，100례미감염HIV적TB환자위대조조，대량조환자진행결핵균소（PPD）시험、담결핵균배양、결핵항체화γ간우소석방시험（IGRA）진행진단。결과대조조환자PPD시험、담결핵균배양화결핵항체양성솔명현고우관찰조환자，차이유통계학의의（P＜0．01）；이IGRA양성솔량조비교，차이무통계학의의（P＞0．05）；관찰조IGRA양성명현고우PPD시험、담결핵균배양화결핵항체양성솔，균차이유통계학의의（P＜0．01）。항역전록병독치료관찰조환자IGRA음성발생솔명현고우양성솔，차이유통계학의의（P＜0．05）。결론IGRA시진단HIV감염합병TB적민감방법，이항역전록병독치료가능대결과유일정적영향。
Objective To evaluate the value of the four kinds of diagnostic method in acquired immune deficiency syndrome (AIDS) infection complicating tuberculosis (TB) .Methods 52 cases of human immunodeficiency virus (HIV) infection complica‐ting TB were taken as the observation group and 100 cases of TB without complicating HIV infection were taken as the control group .The two groups were performed the PPD test ,sputum Mycobacterium tuberculosis culture ,tuberculosis antibody and inter‐feron gamma release assay(IGRA) for conducting the diagnosis .Results The positive rate of the PPD test ,sputum Mycobacterium tuberculosis culture and tuberculosis antibody in the control group were significantly higher than those in the observation group ,the differences were statistically significant (P<0 .01);the positive rate of the IGRA in the observation group was obviously higher than that of the PPD test ,sputum Mycobacterium tuberculosis culture and tuberculosis antibody ,the differences had statistical sig‐nificance (P<0 .01) .The negative occurrence rate of the IGRA in the observation group treated by the antiretroviral therapy was obviously higher than the positive rate ,the difference was statistically significant (P<0 .05) .Conclusion The IGRA may be a sen‐sitive method for diagnosing HIV infection complicating TB and the antiretroviral therapy may have a certain impact on the results .