CAJ | 학술논문

目的：探讨大肠癌组织中血管内皮生长因子（VEGF）及人巨噬细胞游走抑制因子（MIF）的表达及临床意义。方法选取80份经手术切除并经病理证实为大肠癌的组织蜡块（观察组）及80份距癌肿边缘5cm以上经病理证实无癌细胞残存的正常大肠组织（对照组），SP法检测VEGF、MIF在大肠癌及正常大肠组织中的表达。结果VEGF，MIF在观察组中阳性率为77．50％、82．50％，在对照组阳性率为22．50％、27．50％，观察组阳性率明显高于对照组，差异有统计学意义（P＜0．05）。VEGF、MIF在大肠癌组织中的表达与肿瘤的浸润深度、淋巴结转移、临床分期相关，与性别、年龄、组织学分化无关。结论VEGF、MIF在大肠癌组织中高表达。
목적：탐토대장암조직중혈관내피생장인자（VEGF）급인거서세포유주억제인자（MIF）적표체급림상의의。방법선취80빈경수술절제병경병리증실위대장암적조직사괴（관찰조）급80빈거암종변연5cm이상경병리증실무암세포잔존적정상대장조직（대조조），SP법검측VEGF、MIF재대장암급정상대장조직중적표체。결과VEGF，MIF재관찰조중양성솔위77．50％、82．50％，재대조조양성솔위22．50％、27．50％，관찰조양성솔명현고우대조조，차이유통계학의의（P＜0．05）。VEGF、MIF재대장암조직중적표체여종류적침윤심도、림파결전이、림상분기상관，여성별、년령、조직학분화무관。결론VEGF、MIF재대장암조직중고표체。
Objective Todetecttheexpressionofvascularendothelialgrowthfactor(VEGF)andmigrationinhibitoryfactor (MIF) in colorectal cancer .Methods The immunohistochemical staining (SP method) was used to measure the expression of VEGF and MIF in 80 samples of colorectal cancer and 80 samples of normal colorectal tissues at 5 cm apart from the tumor edge . The relationship between VEGF and MIF with the clinical pathologic characteristics of colorectal cancer was anlyzed .Results The positive rates of VEGF and MIF in the colorectal cancer tissues were 77 .50% and 82 .50% respectively ,but which in the normal colorectal tissues were 22 .50% and 27 .50% respectively ,the positive rate of VEGF and MIF expression in the colorectal cancer tis‐sues were higher than that in the normal colorectal tissue with statistical difference (P<0 .05) .The expression of VEGF and MIF had correlation with the tumor infiltration depth ,lymph node metastasis ,and clinical stage ,but no correlation with gender ,age and histodifferentiation .Conclusion VEGF and MIF are highly expressed in the colorectal cancer tissues .