CAJ | 학술논문

目的：探讨全反式维甲酸( ATRA)联合三氧化二砷( ATO)治疗急性早幼粒细胞白血病( APL)过程中血清血脂的变化规律。方法回顾分析经全反式维甲酸联合三氧化二砷诱导完全缓解后，两种药物联合巩固治疗2个周期的急性早幼粒细胞白血病住院患者49例。分别于治疗前、完全缓解后( CR)、联合用药巩固治疗第1个周期结束及第2周期结束，检测血清血脂指标-血清三酰甘油( TG)、血清总胆固醇( TC)。并对血脂指标进行统计学分析。结果经ATRA联合ATO治疗完全缓解后，患者血脂与治疗前比较，差异无统计学意义( P>0．05)。完全缓解后巩固治疗1个周期，血清TG及TC 水平升高(P<0．05)。完全缓解后巩固治疗2个周期，分别与治疗前、完全缓解后及巩固治疗1个周期比较，血清TG及TC升高( P<0．01)。结论 APL患者经AT-RA联合ATO治疗会导致血脂升高。
목적：탐토전반식유갑산( ATRA)연합삼양화이신( ATO)치료급성조유립세포백혈병( APL)과정중혈청혈지적변화규률。방법회고분석경전반식유갑산연합삼양화이신유도완전완해후，량충약물연합공고치료2개주기적급성조유립세포백혈병주원환자49례。분별우치료전、완전완해후( CR)、연합용약공고치료제1개주기결속급제2주기결속，검측혈청혈지지표-혈청삼선감유( TG)、혈청총담고순( TC)。병대혈지지표진행통계학분석。결과경ATRA연합ATO치료완전완해후，환자혈지여치료전비교，차이무통계학의의( P>0．05)。완전완해후공고치료1개주기，혈청TG급TC 수평승고(P<0．05)。완전완해후공고치료2개주기，분별여치료전、완전완해후급공고치료1개주기비교，혈청TG급TC승고( P<0．01)。결론 APL환자경AT-RA연합ATO치료회도치혈지승고。
Objective To explore the changes of serum lipid of acute promyelocytic leukemia ( APL) treated by all-trans retinoic acid in combination with arsenic trioxide. Methods 49 hospitalized patients with acute promyelo-cytic leukemia who attained complete remission by using all-trans retinoic acid in combination with arsenic trioxide and then consolidated for two cycles were retrospectively analyzed. The index of serum lipid( serum triglycerides,serum to-tal cholesterol) were detected and statistical analysis was performed respectively before treatment,after complete remis-sion ( CR) ,at the end of the first and second cycle of combination consolidation treatment. Results After complete re-mission, no significant change was observed in the indexes of serum lipid (P>0. 05). At the end of the first cycle of combination consolidation treatment, the serum triglyceride and cholesterol increased (P<0. 05);and the indexes con-tinued to raise at the end of the second cycle of treatment (P<0. 01). Conclusion Patients with APL treated by AT-RA combined with ATO can lead to elevated blood lipids.