CAJ | 학술논문

目的：探讨高通量血液透析联合复方α酮酸片对血液透析患者营养不良及微炎症状态的影响。方法将102例行维持性血液透析患者随机分为3组。 A组患者采用普通通量血液透析模式,B组患者采用高通量血液透析模式,C组患者在采用高通量血液透析的基础上联合复方α酮酸片治疗。治疗观察6个月。比较三组透析患者的血肌酐、尿素氮、血清总蛋白、血清白蛋白等生化指标,人体测量学指标,超敏 C反应蛋白( hs-CRP)、白介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)微炎症指标。结果干预6个月后,C组患者BMI、MAC、TSF、TP、ALB 升高( P <0．05),且高于 A 组( P <0．05)；hs-CRP、IL-6水平降低( P <0．05),且低于其他两组；TNF-α明显降低(P<0．05),与其他两组比较差异无统计学意义(P>0．05)。结论高通量血液透析联合复方α酮酸可明显改善维持性血液透析患者的营养状况,对微炎症状态控制良好,优于单用高通量血液透析或普通血液透析。
목적：탐토고통량혈액투석연합복방α동산편대혈액투석환자영양불량급미염증상태적영향。방법장102례행유지성혈액투석환자수궤분위3조。 A조환자채용보통통량혈액투석모식,B조환자채용고통량혈액투석모식,C조환자재채용고통량혈액투석적기출상연합복방α동산편치료。치료관찰6개월。비교삼조투석환자적혈기항、뇨소담、혈청총단백、혈청백단백등생화지표,인체측량학지표,초민 C반응단백( hs-CRP)、백개소-6(IL-6)이급종류배사인자-α(TNF-α)미염증지표。결과간예6개월후,C조환자BMI、MAC、TSF、TP、ALB 승고( P <0．05),차고우 A 조( P <0．05)；hs-CRP、IL-6수평강저( P <0．05),차저우기타량조；TNF-α명현강저(P<0．05),여기타량조비교차이무통계학의의(P>0．05)。결론고통량혈액투석연합복방α동산가명현개선유지성혈액투석환자적영양상황,대미염증상태공제량호,우우단용고통량혈액투석혹보통혈액투석。
Objective To investigate the effect of high-flux hemodialysis with compound α-keto acid tablets on malnutrition and micro-inflammatory state. Methods 102 MHD ( maintenance hemodialysis) patients were random-ly divided into 3 groups,patients in group A,group B and group C received ordinary flux hemodialysis mode,high-flux hemodialysis mode and high-flux hemodialysis with compound α-keto acid tablets therapy respectively. The treatment lasted for 6 months. The serum creatinine,blood urea nitrogen,serum total protein,serum ALB and other biochemical indicators,anthropometric indicators,changes of hs-CRP,IL-6 and TNF-α in the three groups were compared. Results The BMI,MAC,TSF,TP and ALB of group C increased significantly (P<0. 05),and there were significant differ-ences between group C and group A (P<0. 05);hs-CRP,IL-6 (compared with another groups,P<0. 05) and TNF-α(compared with another groups,P>0. 05) significantly decreased in group C (P<0. 05). Conclusion High flux he-modialysis with compound α-keto acid can significantly improve the malnutrition, micro-inflammatory state of MHD patients,the effect is better than single high-flux or low-flux hemodialysis.