CAJ | 학술논문

目的：应用无创血流动力学监测观察新活素(重组人脑利钠肽)对老年顽固性心力衰竭患者血流动力学参数的影响。方法选取2012年1月至2013年10月收治的老年顽固性心力衰竭患者38例，随机分为试验组(新活素)和对照组。两组治疗前后分别应用BioZ ICG无创血流动力学监测仪。选取10种血流动力学参数：心率( HR)、收缩压( SBP)、心输出量( CO)、心脏指数( CI)、每搏输出量( SV)、每搏指数( SI)、速度指数( VI)、加速指数( ACI)、预射血期( PEP)、收缩时间比率( STR)进行血流动力学定量评估。结果治疗后，试验组与对照组比较，心率减慢，输出量/心脏指数、每搏输出量、每搏指数明显提高(P<0．05)，预射血期、收缩时间比率明显缩短(P<0．05)，血浆脑利钠肽浓度(BNP)显著下降(P<0．05)，收缩压、速度指数、加速指数差异无统计学意义。结论新活素治疗老年顽固性心力衰竭具有较好的血流动力学效应，而无创血流动力学监测可作为评估心衰治疗的量化指标。
목적：응용무창혈류동역학감측관찰신활소(중조인뇌리납태)대노년완고성심력쇠갈환자혈류동역학삼수적영향。방법선취2012년1월지2013년10월수치적노년완고성심력쇠갈환자38례，수궤분위시험조(신활소)화대조조。량조치료전후분별응용BioZ ICG무창혈류동역학감측의。선취10충혈류동역학삼수：심솔( HR)、수축압( SBP)、심수출량( CO)、심장지수( CI)、매박수출량( SV)、매박지수( SI)、속도지수( VI)、가속지수( ACI)、예사혈기( PEP)、수축시간비솔( STR)진행혈류동역학정량평고。결과치료후，시험조여대조조비교，심솔감만，수출량/심장지수、매박수출량、매박지수명현제고(P<0．05)，예사혈기、수축시간비솔명현축단(P<0．05)，혈장뇌리납태농도(BNP)현저하강(P<0．05)，수축압、속도지수、가속지수차이무통계학의의。결론신활소치료노년완고성심력쇠갈구유교호적혈류동역학효응，이무창혈류동역학감측가작위평고심쇠치료적양화지표。
Objective To observe the effect of recombinant human brain natriuretic peptide on hemodynamic parameters in the elderly patients with refractory heart failure by using the noninvasive hemodynamic monitor. Methods Thirty-eight patients with refractory heart failure were randomly divided into experimental group ( recombinant hu-man brain natriuretic peptide) and control group. The BioZ ICG noninvasive hemodynamic monitoring was used before and after treatment. Ten hemodynamic parameters including heart rate (HR),systolic blood pressure (SBP),cardiac output ( CO) ,cardiac index ( CI) output,stroke volume ( SV) ,stroke index ( SI) ,velocity index ( VI) ,acceleration in-dex ( ACI) ,pre-ejection period ( PEP) ,systolic time ratio ( STR) were evaluated. Results After treatment,compared with control group,HR,PEP,STR in experimental group significantly decreased (P<0. 05),CO,CI,SV and SI were significantly improved(P<0. 05),plasma brain natriuretic peptide concentration decreased significantly (P<0. 05);there was no significant difference in the SBP,VI and ACI between the two groups (P>0. 05). Conclusion The re-combinant human brain natriuretic peptide results in effective hemodynamic improvements in the elderly patients with refractory heart failure, and noninvasive hemodynamic monitoring can be used as a quantitative index for evaluating heart failure treatment.