CAJ | 학술논문

目的：探讨Ⅲ型前列腺炎（CP／CPPS）患者血清和前列腺按摩液（EPS）中雌二醇（E2）、睾酮（T）水平与勃起功能的关系。方法应用放射免疫法检测64例CP／CPPS患者和20例健康对照者血清、EPS中E2、T的水平，其中ⅢA组35例，ⅢB组29例，所有患者行前列腺炎症状指数（NIH‐CPSI）和勃起功能国际指数（IIEF‐5）评分。并按IIEF‐5分值分组，其中勃起功能障碍（ED）组32例，非ED组32例，比较各组数据。结果ⅢA组和ⅢB组血清、EPS中E2／T水平均高于对照组，差异有统计学意义（P＜0．05）。ⅢA组中ED患者20例（57．14％）多于ⅢB组12例（41．38％），但差异无统计学意义（P＞0．05）。CP／CPPS组的IIEF‐5评分与血清、EPS中T水平呈正相关（r＝0．218、r＝0．231，P＜0．05），与血清、EPS中E2／T呈负相关（r＝－0．189、r＝－0．652，P＜0．05），与NIH‐CPSI评分无相关（P＞0．05）。ED组血清T（6．32±1．86）ng／mL低于非ED组（7．89±2．92）ng／mL和对照组（8．41±2．02）ng／mL；ED组EPS中E2／T（55．02±29．26）明显高于非ED组（14．06±9．36）和对照组（16．45±13．76），差异有统计学意义（P＜0．05）。结论血清和EPS中雌雄激素失衡程度与CP／CPPS患者勃起功能相关。
목적：탐토Ⅲ형전렬선염（CP／CPPS）환자혈청화전렬선안마액（EPS）중자이순（E2）、고동（T）수평여발기공능적관계。방법응용방사면역법검측64례CP／CPPS환자화20례건강대조자혈청、EPS중E2、T적수평，기중ⅢA조35례，ⅢB조29례，소유환자행전렬선염증상지수（NIH‐CPSI）화발기공능국제지수（IIEF‐5）평분。병안IIEF‐5분치분조，기중발기공능장애（ED）조32례，비ED조32례，비교각조수거。결과ⅢA조화ⅢB조혈청、EPS중E2／T수평균고우대조조，차이유통계학의의（P＜0．05）。ⅢA조중ED환자20례（57．14％）다우ⅢB조12례（41．38％），단차이무통계학의의（P＞0．05）。CP／CPPS조적IIEF‐5평분여혈청、EPS중T수평정정상관（r＝0．218、r＝0．231，P＜0．05），여혈청、EPS중E2／T정부상관（r＝－0．189、r＝－0．652，P＜0．05），여NIH‐CPSI평분무상관（P＞0．05）。ED조혈청T（6．32±1．86）ng／mL저우비ED조（7．89±2．92）ng／mL화대조조（8．41±2．02）ng／mL；ED조EPS중E2／T（55．02±29．26）명현고우비ED조（14．06±9．36）화대조조（16．45±13．76），차이유통계학의의（P＜0．05）。결론혈청화EPS중자웅격소실형정도여CP／CPPS환자발기공능상관。
Objective To explore the correlation between the levels of estradiol E2 and testosterone T in serum and expressed prostatic secretion(EPS) with the erectile function in the patients with type Ⅲ prostatitis(CP/CPPS) .Methods The E2 and T lev‐els in serum and EPS from 64 cases of CP/CPPS ,including 35 cases of type Ⅲ A and 29 cases of Ⅲ B ,and 20 individuals of physical examination were detected by using the radioimmunoassay .All cases were evaluated by the scores of NIH‐CPSI and the Internation‐al Index of Erectile Function 5(IIEF‐5) .64 patients were grouped according to the IIEF‐5 scores ,the erectile dysfunction(ED) group(32 cases) and the non‐ED group(32 cases) .Results The mean E2/T levels in serum and EPS of the Ⅲ A group and the Ⅲ B group were higher than those in the control group ,the difference had statistical significance(P<0 .05) .20 cases(57 .14% ) of ED were found in the Ⅲ A group ,which were more than 12 cases(41 .38% ) of ED in the Ⅲ B group ,but there was no statistically signifi‐cant difference (>0 .05 .There was a positive correlation between the IIEF‐5 score and the T level in serum and EPS in the CP/CPPS group(r=0 .218 ,r=0 .231 ,P<0 .05) .There was a negative correlation between the IIEF‐5 score and the E2/T level in ser‐um and EPS(r= -0 .189 ,r= -0 .652 ,P<0 .05) ,which had no correlation with the NIH‐CPSI score(P>0 .05) .The serum T level in the ED group was (6 .32 ± 1 .86)ng/mL ,which was lower than(7 .89 ± 2 .92)ng/mL in the non‐ED group and (8 .41 ± 2 .02)ng/mL in the control group ;the .E2/T level in EPS in the ED group was (55 .02 ± 29 .26) ,which was higher than (14 .06 ± 9 .36) in the non‐ED group and (16 .45 ± 13 .76) in the control group ,the differences among them were statistically significant (P<0 .05) .Con‐clusion The imbalance degree of hormone estradiol and testosterone in serum and EPS is related with erectile function in the pa‐tients with CP/CPPS .