CAJ | 학술논문

目的：探讨e抗原阳性慢性乙型肝炎临床分度与拉米夫定抗病毒疗效的关系。方法选择按肝功能损伤程度分轻、中、重度e抗原阳性慢性乙型肝炎患者，各15例，均完成48周LAM 100 mg/d治疗，治疗期间定期复查肝功能、HBV标志物及HBV DNA水平，分别比较轻、中、重度三组患者在治疗3个月、6个月及1年的e抗原及HBV-DNA转阴率和ALT复常率。结果治疗3个月、6个月及1年后e抗原阳性慢性乙型肝炎轻、中、重度三组患者ALT复常率、HBV-DNA和e抗原转阴率有不同程度的改善，而中、重度二组患者HBV-DNA及e抗原转阴率明显高于轻度患者（P＜0.05）。结论 e抗原阳性慢性乙型肝炎中、重度对拉米夫定抗病毒疗效最好。
목적：탐토e항원양성만성을형간염림상분도여랍미부정항병독료효적관계。방법선택안간공능손상정도분경、중、중도e항원양성만성을형간염환자，각15례，균완성48주LAM 100 mg/d치료，치료기간정기복사간공능、HBV표지물급HBV DNA수평，분별비교경、중、중도삼조환자재치료3개월、6개월급1년적e항원급HBV-DNA전음솔화ALT복상솔。결과치료3개월、6개월급1년후e항원양성만성을형간염경、중、중도삼조환자ALT복상솔、HBV-DNA화e항원전음솔유불동정도적개선，이중、중도이조환자HBV-DNA급e항원전음솔명현고우경도환자（P＜0.05）。결론 e항원양성만성을형간염중、중도대랍미부정항병독료효최호。
ObjectiveTo investigate the relationship between the clinical graduation of e antigen-positive Hepatitis B and the therapeutic effect of lamivudine in anti-HBV.Methods45 e antigen-positive patients were equal divided in to three groups:mild,moderate and severe,according to liver function lesion.All patients received on LAM 100mg/d for at least 48 weeks.The liver function,serum HBV markers and Hepatic Viral load were regularly checked during the treatment in 3,6 and 12 months.To compare the negative conversion ratios of e antigen,HBV-DNA and ALT in the three groups patients above respectively.ResultsThe three groups patients achieved different degrees of improvement in the negative conversion ratios of e antigen,HBV-DNA and ALT,and the negative conversion ratios of e antigen,HBV-DNA in moderate and severe groups are apparently higher than mild group (P<0.05).ConclusionThe moderate and severe e antigen-positive chronic hepatitis can get the best therapeutic effect of lamivudine in anti-HBV.