实用药物与临床
實用藥物與臨床
실용약물여림상
PRACTICAL PHARMACY AND CLINICAL REMEDIES
2015年
4期
478-481
,共4页
双相情感障碍%抑郁发作%安非他酮%喹硫平
雙相情感障礙%抑鬱髮作%安非他酮%喹硫平
쌍상정감장애%억욱발작%안비타동%규류평
Bipolar disorder%Depressive episodes%Bupropion%Quetiapine
目的:探讨安非他酮与喹硫平治疗双相情感障碍抑郁发作的临床疗效及安全性。方法将双相情感障碍抑郁发作患者68例随机分为安非他酮组和喹硫平组,每组34例,分别口服安非他酮与喹硫平治疗。采用汉密顿抑郁量表( HAMD )评定其临床疗效,用生活质量问卷( GQOLI )评定生活质量,应用副反应量表(TESS)评定不良反应。结果治疗后,两组HAMD评分均降低(P<0.05);治疗第1、2、4、6、8周,喹硫平组较安非他酮组降低,差异有统计学意义(P<0.05);喹硫平组显效率高于安非他酮组(P<0.05)。治疗8周后,喹硫平组躯体功能、心理功能、社会功能及GQOLI总分提高( P<0.05)。喹硫平组不良反应发生率、TESS评分低于安非他酮组(P<0.05),差异有统计学意义(P<0.05)。结论喹硫平治疗双相情感障碍抑郁发作疗效显著,患者依从性好,安全性高,可明显提高患者的生活质量,效果优于安非他酮。
目的:探討安非他酮與喹硫平治療雙相情感障礙抑鬱髮作的臨床療效及安全性。方法將雙相情感障礙抑鬱髮作患者68例隨機分為安非他酮組和喹硫平組,每組34例,分彆口服安非他酮與喹硫平治療。採用漢密頓抑鬱量錶( HAMD )評定其臨床療效,用生活質量問捲( GQOLI )評定生活質量,應用副反應量錶(TESS)評定不良反應。結果治療後,兩組HAMD評分均降低(P<0.05);治療第1、2、4、6、8週,喹硫平組較安非他酮組降低,差異有統計學意義(P<0.05);喹硫平組顯效率高于安非他酮組(P<0.05)。治療8週後,喹硫平組軀體功能、心理功能、社會功能及GQOLI總分提高( P<0.05)。喹硫平組不良反應髮生率、TESS評分低于安非他酮組(P<0.05),差異有統計學意義(P<0.05)。結論喹硫平治療雙相情感障礙抑鬱髮作療效顯著,患者依從性好,安全性高,可明顯提高患者的生活質量,效果優于安非他酮。
목적:탐토안비타동여규류평치료쌍상정감장애억욱발작적림상료효급안전성。방법장쌍상정감장애억욱발작환자68례수궤분위안비타동조화규류평조,매조34례,분별구복안비타동여규류평치료。채용한밀돈억욱량표( HAMD )평정기림상료효,용생활질량문권( GQOLI )평정생활질량,응용부반응량표(TESS)평정불량반응。결과치료후,량조HAMD평분균강저(P<0.05);치료제1、2、4、6、8주,규류평조교안비타동조강저,차이유통계학의의(P<0.05);규류평조현효솔고우안비타동조(P<0.05)。치료8주후,규류평조구체공능、심리공능、사회공능급GQOLI총분제고( P<0.05)。규류평조불량반응발생솔、TESS평분저우안비타동조(P<0.05),차이유통계학의의(P<0.05)。결론규류평치료쌍상정감장애억욱발작료효현저,환자의종성호,안전성고,가명현제고환자적생활질량,효과우우안비타동。
Objective To investigate the clinical efficacy and safety of bupropion and quetiapine on depressive episodes of bipolar disorder. Methods 68 patients with depressive episodes of bipolar disorder were randomly divided into bupropion group and quetiapine group,34 cases in each group,patients received bupropion and quetiapine oral treatment respectively. The Hamilton depression rating scale ( HAMD) ,generic quality of life inventory ( GQOLI) and treatment emergent symptom scale (TESS) were used to assess the clinical efficacy,quality of life and adverse reac-tions. Results After treatment,HAMD score of the two groups decreased significantly (P<0. 05),and the scores of patients in quetiapine group were lower than those of bupropion group at the 1st,2nd,4th,6th,8th week (P<0. 05), the effective rate of quetiapine group was higher than that of bupropion group (P<0. 05). After 8 weeks of treatment, the physical function,psychological function, social function and total score in GQOLI significantly increased ( P <0. 05). The rate of adverse drug reaction and TESS scores of quetiapine group were significantly lower than those of bu-propion group (P<0. 05). Conclusion The efficacy of quetiapine on depressive episodes of bipolar disorder is signif-icant,with good compliance and high safety,it can significantly improve the quality of life,and the effect is better than bupropion.