CAJ | 학술논문

半个多世纪以来，活性维生素D3，即1，25－二羟维生素D3[1－25（OH）2D3]在糖尿病相关治疗研究中成为热点。由于1－25（OH）2D3及其特异性受体在糖尿病肾病中有一定抑制肾脏纤维化作用而备受关注。其可能通过参与抑制肾素－血管紧张素系统激活、减少纤维化因子释放及氧化应激等过程发挥作用，目前机制尚未完全明确。该文针对1－25（OH）2D3及其受体在肾脏中的表达及其相互作用进行阐述，以期为糖尿病的预防和诊治带来新的契机。
반개다세기이래，활성유생소D3，즉1，25－이간유생소D3[1－25（OH）2D3]재당뇨병상관치료연구중성위열점。유우1－25（OH）2D3급기특이성수체재당뇨병신병중유일정억제신장섬유화작용이비수관주。기가능통과삼여억제신소－혈관긴장소계통격활、감소섬유화인자석방급양화응격등과정발휘작용，목전궤제상미완전명학。해문침대1－25（OH）2D3급기수체재신장중적표체급기상호작용진행천술，이기위당뇨병적예방화진치대래신적계궤。
For more than half a century,the research of active vitamin D3(1,25-(OH)2D3) has been the hot spot of diabetic nephropathy(DN) therapy.Active vitamin D3 and its specific receptors vitamin D receptor (VDR) play a protective role in renal fibrosis of DN.It may suppress the activation of renin-angio-tensin system ( RAS) system,reduce the release of fibrosis factors and the oxidative stress ,though the underly-ing mechanism is still unclear.Here mainly expounds the positive effects and interaction of active vitamin D 3 and VDR in the regulation of DN which may bring a new opportunity for the prevention and treatment of DN .