CAJ | 학술논문

目的：探讨转化生长因子β1（ TGF－β1）与人类 Runt相关转录因子3（ Runx3）在结肠癌中的表达及其两者表达的相关性。方法收集2011年1月至2013年12月安岳县人民医院收治的结肠癌患者34例、结肠腺瘤性息肉患者34例标本以及正常体检的34例结肠黏膜标本，通过免疫组织化学SP法检测Runx3、TGF－β1的表达，分析 Runx3与 TGF－β1在结肠癌中的相关性。结果 Runx3在结肠癌组织中表达阳性率最低（17.7％，6／34），与结肠黏膜和结肠息肉组织比较差异均有统计学意义（P＜0.01）。 TGF－β1在结肠癌组织中的阳性表达率为88.3％（30／34），显著高于结肠息肉和结肠黏膜组织，差异均有统计学意义（P ＜0.01）。结肠癌中 TGF－β1与 Runx3表达呈负相关（rs ＝－0.46，P＜0.05）。结论 Runx3及TGF－β1在不同结肠组织中表达差异明显，在结肠癌组织中表达有相关性，检测Runx3和TGF－β1可能为结肠癌早期诊断提供一定依据。
목적：탐토전화생장인자β1（ TGF－β1）여인류 Runt상관전록인자3（ Runx3）재결장암중적표체급기량자표체적상관성。방법수집2011년1월지2013년12월안악현인민의원수치적결장암환자34례、결장선류성식육환자34례표본이급정상체검적34례결장점막표본，통과면역조직화학SP법검측Runx3、TGF－β1적표체，분석 Runx3여 TGF－β1재결장암중적상관성。결과 Runx3재결장암조직중표체양성솔최저（17.7％，6／34），여결장점막화결장식육조직비교차이균유통계학의의（P＜0.01）。 TGF－β1재결장암조직중적양성표체솔위88.3％（30／34），현저고우결장식육화결장점막조직，차이균유통계학의의（P ＜0.01）。결장암중 TGF－β1여 Runx3표체정부상관（rs ＝－0.46，P＜0.05）。결론 Runx3급TGF－β1재불동결장조직중표체차이명현，재결장암조직중표체유상관성，검측Runx3화TGF－β1가능위결장암조기진단제공일정의거。
Objective To investigate the expression of transforming growth factor -β1 ( TGF-β1 ) and Runt-related transcription factor 3(Runx3) in colon cancer,and their correlation.Methods A total of 34 patients with colon cancer and 34 patients with colonic adenomatous polyp admitted in Anyue People′s Hos-pital from Jan.2011 to Dec.2013 were selected as research objects,and another 34 cases of normal colon mu-cosa specimens from physical examination were selected as the normal control,the expression of Runx3 and TGF-β1 in the three groups was detected by immunohistochemical method,and correlation between Runx3 and TGF-β1 in colon cancer was analyzed.Results The expression of Runx3 in colon cancer tissues was the lowest (17.7%,6/34),and the differences with the other two groups were statistically significant (P <0.01).The positive expression rate of TGF-β1 in colon cancer (88.3%,30/34) was significantly higher than that in colonic adenomatous polyp and normal colon mucosa ,the differences were statistically significant (P<0.01).The expression of TGF-β1 and Runx3 in colon cancer were negatively correlated(rs =-0.46, P<0.05).Conclusion The expression of Runx3 and TGF-β1 in different colon tissues is significantly dif-ferent,and correlates with each other in colon cancer.Detection of Runx3 and TGF-β1 may provide a basis for early diagnosis of colon cancer.