CAJ | 학술논문

目的：分析还原型谷胱甘肽对早期糖尿病患者尿白蛋白排泄率及炎性因子的影响。方法选择2012年9月至2013年7月屯昌县人民医院收治的早期糖尿病肾病患者76例，采用随机数字表法分为观察组与对照组，各38例。观察组给予1.2 g还原型谷胱甘肽静脉滴注，每日1次，连续治疗28 d；对照组给予1.2 g血塞通针静脉滴注，每日1次，连续治疗28 d。同期选取38例健康体检者作为正常对照组，未给予治疗措施。对比分析治疗前及治疗28 d 后3组受试者血清白细胞介素6（IL－6）、肿瘤坏死因子α（TNF－α）、C反应蛋白（CRP）水平，以及早期糖尿病肾病患者的尿白蛋白排泄率（ UAER）。结果治疗前，观察组与对照组患者的血清 IL－6、TNF－α及 CRP 水平均显著高于正常对照组（P＜0.01）。治疗28 d后，观察组血清 IL－6、TNF－α及 CRP水平显著下降（P＜0.01）。观察组治疗前后UAER水平分别为（160±28） mg和（106±24） mg，治疗前后比较差异有统计学意义（P＜0.01）。结论还原型谷胱甘肽能减轻早期糖尿病肾病患者的炎症状态，延缓糖尿病肾病的进展。
목적：분석환원형곡광감태대조기당뇨병환자뇨백단백배설솔급염성인자적영향。방법선택2012년9월지2013년7월둔창현인민의원수치적조기당뇨병신병환자76례，채용수궤수자표법분위관찰조여대조조，각38례。관찰조급여1.2 g환원형곡광감태정맥적주，매일1차，련속치료28 d；대조조급여1.2 g혈새통침정맥적주，매일1차，련속치료28 d。동기선취38례건강체검자작위정상대조조，미급여치료조시。대비분석치료전급치료28 d 후3조수시자혈청백세포개소6（IL－6）、종류배사인자α（TNF－α）、C반응단백（CRP）수평，이급조기당뇨병신병환자적뇨백단백배설솔（ UAER）。결과치료전，관찰조여대조조환자적혈청 IL－6、TNF－α급 CRP 수평균현저고우정상대조조（P＜0.01）。치료28 d후，관찰조혈청 IL－6、TNF－α급 CRP수평현저하강（P＜0.01）。관찰조치료전후UAER수평분별위（160±28） mg화（106±24） mg，치료전후비교차이유통계학의의（P＜0.01）。결론환원형곡광감태능감경조기당뇨병신병환자적염증상태，연완당뇨병신병적진전。
Objective To analyze the effects of reduced glutathione on urine albumin excretion rate and inflammatory factors in patients with early diabetes.Methods A total of 76 patients with early diabetic nephropathy admitted in Tunchang County People′s Hospital from Sep.2012 to Jul.2013 were randomly divided into observation group and control group,with 38 cases in each group.Patients in the observation group were given intravenous infusion of 1.2 g glutathione,once per day,continuous treatment for 28 d,while patients in the control group received intravenous injection of 1.2 g Xuesaitong,once per day,continuous treatment for 28 d.Meanwhile,another 38 healthy people underwent physical examination during the same period were selected as normal control group.The serum levels of interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α),C reactive protein(CRP) of the three groups before treatment and 28 days after treatment, and urinary albumin excretion rate(UAER)in those patients with early diabetic nephropathy before treatment and 28 d after treatment were comparatively analyzed .Results Before treatment,serum levels of IL-6,TNF-αand CRP in the observation group and the control group were significantly higher than those in normal con-trol group (P<0.01),and 28 d after treatment,such levels of the observation group decreased significantly (P<0.01).Levels of UAER before and after treatment in the observation group were (160 ±28) mg/and (106 ±24) mg,the difference was statistically significant(P <0.01).Conclusion Reduced glutathione can alleviate the inflammatory status in patients with early diabetic nephropathy ,and effectively slow down the progression of early diabetic nephropathy.