CAJ | 학술논문

目的：观察复方α－酮酸联合醋酸钙对维持性血液透析患者钙磷代谢的影响。方法将2010年1月至2014年12月绵阳市中心医院收治的99例维持性血液透析高磷血症患者采用随机数字表法分为联合组（醋酸钙＋复方α－酮酸）（31例）、醋酸钙组（醋酸钙）（38例）和对照组（低磷饮食）（30例），疗程12周。比较三组患者的钙磷代谢及营养状况。结果治疗后3个月，三组患者的血磷、血钙磷乘积、血清甲状旁腺激素（PTH）比较差异有统计学意义（P＜0.05），血钙3组差异无统计学意义（P＞0.05）；治疗后3个月，三组白蛋白比较差异有统计学意义（P＜0.05），肌酐和尿素水平三组比较差异无统计学意义（P＞0.05）。结论复方α－酮酸联合醋酸钙可用于治疗慢性肾脏病血透患者高磷血症，有效降低血磷、血钙磷乘积、PTH水平。
목적：관찰복방α－동산연합작산개대유지성혈액투석환자개린대사적영향。방법장2010년1월지2014년12월면양시중심의원수치적99례유지성혈액투석고린혈증환자채용수궤수자표법분위연합조（작산개＋복방α－동산）（31례）、작산개조（작산개）（38례）화대조조（저린음식）（30례），료정12주。비교삼조환자적개린대사급영양상황。결과치료후3개월，삼조환자적혈린、혈개린승적、혈청갑상방선격소（PTH）비교차이유통계학의의（P＜0.05），혈개3조차이무통계학의의（P＞0.05）；치료후3개월，삼조백단백비교차이유통계학의의（P＜0.05），기항화뇨소수평삼조비교차이무통계학의의（P＞0.05）。결론복방α－동산연합작산개가용우치료만성신장병혈투환자고린혈증，유효강저혈린、혈개린승적、PTH수평。
Objective To investigate the effect of α-keto acid combined calcium acetate in maintaining hemodialysis patients.Methods Ninety-nine patients with maintenance hemodialysis admitted to the Central Hospital of Mianyang from January 2010 to December 2014 were randomly divided into the combined group , calcium acetate group and the control group.The combined group received α-keto acid and calcium acetate, the calcium acetate group received calcium acetate,while the control group don′t received α-keto acid and calcium acetate and it just to give a low phosphorus diet .Calcium and phosphorus metabolism and nutritional status were compared between the three groups.All groups were treated for 12 weeks.Results After 3 months,three groups of patients with the serum P3+, Ca2+×P3+,and PTH levels comparative difference were statistically significant(P<0.05).The blood calcium levels in the combined group was higher than that in the other two groups,but there was no statistically significant difference(P>0.05).The albumin was sta-tistically significant(P<0.05).Serum creatinine and blood urea nitrogen in the combined group were lower than those in the other two groups,but here were no statistically significant difference(P>0.05).Conclu-sion α-keto acid combined calcium acetate acid can improve calcium and phosphorus metabolism disorder and can reduce the serum P3+,Ca2+×P3+,PTH levels.