CAJ | 학술논문

目的：观察分析宫颈癌患者血清及组织基质金属蛋白酶（MMP）及环氧化酶-2（COX-2）、细胞外MMP诱导因子CD147、胰岛素样生长因子（IGF）的变化情况。方法选取2012年3月至2014年3月79例宫颈癌患者为观察组，并以同期的79例健康妇女为对照组，将两组的MMP及COX-2、CD147、IGF血清水平及组织阳性率分别进行统计及比较，同时比较观察组中不同分期宫颈癌患者的血清水平及组织阳性率。结果观察组的MMP及COX-2、CD147、IGF血清水平及组织阳性率均高于对照组，同时观察组中分期较高宫颈癌患者的血清水平及组织阳性率均高于分期较低者，各个比较项目之间差异均有统计学意义（P均<0.05）。结论宫颈癌患者血清和组织MMP及COX-2、CD147、IGF均呈现高表达状态，并且分期越高者其表达程度越高。
목적：관찰분석궁경암환자혈청급조직기질금속단백매（MMP）급배양화매-2（COX-2）、세포외MMP유도인자CD147、이도소양생장인자（IGF）적변화정황。방법선취2012년3월지2014년3월79례궁경암환자위관찰조，병이동기적79례건강부녀위대조조，장량조적MMP급COX-2、CD147、IGF혈청수평급조직양성솔분별진행통계급비교，동시비교관찰조중불동분기궁경암환자적혈청수평급조직양성솔。결과관찰조적MMP급COX-2、CD147、IGF혈청수평급조직양성솔균고우대조조，동시관찰조중분기교고궁경암환자적혈청수평급조직양성솔균고우분기교저자，각개비교항목지간차이균유통계학의의（P균<0.05）。결론궁경암환자혈청화조직MMP급COX-2、CD147、IGF균정현고표체상태，병차분기월고자기표체정도월고。
Objective To study and analyze the change situation of serum and tissue matrix metalloproteinases(MMP)and cyclo-oxygen-ase-2(COX-2),extracellular matrix metalloproteinase inducer(CD147),insulin-like growth factors(IGF)of patients with cervical carcinoma. Methods 79 patients with cervical carcinoma in our hospital from March 2012 to March 2014 were the observation group,79 healthy women at the same period were the control group,then the serum levels and tissue positive rates of MMP and COX-2,CD147,IGF of two groups were respectively analyzed and compared,and the serum levels and tissue positive rates of observation group with different stages of cervical carcinoma were compared too.Results The e serum levels and tissue positive rates of MMP and COX-2,CD147,IGF of observation group were all higher than those of control group,and the serum levels and tissue positive rates of observation group with higher stages of cervical carcinoma were all higher than those of patients with lower stages of cervical carcinoma,all P<0.05,there were significant differences between all the comparison items. Conclusion The serum and tissue MMP and COX-2,CD147,IGF of patients with cervical carcinoma all show higher expression,and the expression degree of patients with higher staged are higher.