CAJ | 학술논문

抗微生物肽LL－37有多种生物学活性，在感染和免疫疾病方面的研究尤为活跃，以 LL－37为基础的新型抗生素研发也受到重视。近年研究提示，LL－37可能通过影响巨噬细胞、中性粒细胞、内皮细胞和平滑肌细胞等功能而参与动脉粥样硬化的病理生理过程。动物实验显示，LL－37有抑制支架再狭窄的效果。 LL－37也可能通过影响血管新生、创伤修复等机制参与心肌重构。同时，其作为心血管疾病新型生物标志物的价值也有待深入评估。此外，LL－37及其衍生物对心血管疾病的药用价值也有广阔的研究前景。
항미생물태LL－37유다충생물학활성，재감염화면역질병방면적연구우위활약，이 LL－37위기출적신형항생소연발야수도중시。근년연구제시，LL－37가능통과영향거서세포、중성립세포、내피세포화평활기세포등공능이삼여동맥죽양경화적병리생리과정。동물실험현시，LL－37유억제지가재협착적효과。 LL－37야가능통과영향혈관신생、창상수복등궤제삼여심기중구。동시，기작위심혈관질병신형생물표지물적개치야유대심입평고。차외，LL－37급기연생물대심혈관질병적약용개치야유엄활적연구전경。
The human anti-microbial peptide LL-37 has multiple bioactivities .It was much more inten-sively investigated in the field of inflammation and immunity .LL-37 and its derivatives was also expected as hopeful antibiotics.Recent and growing evidence suggests LL-37 is related to the pathophysiology of cardio-vascular diseases.LL-37 may be involved in the pathogenesis of atherosclerosis by modulating the function of macrophages,neutrophils,endothelial cells and vascular smooth muscle cells .Animal experiments indicated that LL-37 has the effect of inhibiting stent restenosis.It may also contribute to angiogenesis and myocardial remodeling.The prognostic and therapeutic values of LL-37 and its derivatives for cardiovascular diseases are intriguing and should be further investigated .