CAJ | 학술논문

肠道病毒71型（EV71）是有高度嗜神经性的正链RNA病毒，属于小RNA病毒科肠道病毒属，近几十年来，EV71在中国大陆、中国台湾、马来西亚等亚太地区流行。 EV71主要引起青少年手足口病和疱疹性咽峡炎，也可引起脑干脑炎等严重并发症，其中神经源性肺水肿（ NPE）是最严重的并发症及主要死亡原因之一。 EV71感染引起NPE的确切发病机制仍不清楚。该文从儿茶酚胺分泌异常、细胞因子异常、免疫紊乱、呼吸肌麻痹、年龄及基因等方面对 EV71感染并发 NPE 的机制进行阐述。
장도병독71형（EV71）시유고도기신경성적정련RNA병독，속우소RNA병독과장도병독속，근궤십년래，EV71재중국대륙、중국태만、마래서아등아태지구류행。 EV71주요인기청소년수족구병화포진성인협염，야가인기뇌간뇌염등엄중병발증，기중신경원성폐수종（ NPE）시최엄중적병발증급주요사망원인지일。 EV71감염인기NPE적학절발병궤제잉불청초。해문종인다분알분비이상、세포인자이상、면역문란、호흡기마비、년령급기인등방면대 EV71감염병발 NPE 적궤제진행천술。
Enterovirus 71 ( EV71 ) , a-highly-neurotropic, positive-sense single-stranded RNA virus, belongs to the Enterovirus genus of Picornaviridae family.In recent decades,EV71 spreads mainly in main-land China,Taiwan,Malaysia and other Asia-pacific regions.EV71 infections mainly cause hand, foot, and mouth disease and herpangina in young children ,though it may also cause brain stem encephalitis ,and circu-lation problems,among which neurogenic pulmonary edema ( NPE) is one of the most serious complications and main causes of death.How EV71 infection causes NPE and its exact pathogenesis is still unclear .Here is make an elaboration focusing on the pathogenesis of EV71 infection combined with NPE from the aspects of abnormal secretion of catecholamine, cytokine abnormalities, immune disorder, respiratory myoparalysis, age, and gene etc.