南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2015年
4期
526-529
,共4页
祝爽爽%周树录%周朝敏%李永强%邹和群
祝爽爽%週樹錄%週朝敏%李永彊%鄒和群
축상상%주수록%주조민%리영강%추화군
特发性膜性肾病%间接免疫荧光%M型磷脂酶A2受体1
特髮性膜性腎病%間接免疫熒光%M型燐脂酶A2受體1
특발성막성신병%간접면역형광%M형린지매A2수체1
idiopathic membranous nephropathy%indirect immunofluorescence%PLA2R1
目的:检测在成人特发性膜性肾病患者肾组织中M型磷脂酶A2受体1(PLA2R1)抗原的阳性率及其与特发性膜性肾病关系。方法选取经肾活检证实的108例肾小球疾病患者,其中包括41例特发性膜性肾病、2例乙型肝炎病毒相关性膜性肾病、8例V型狼疮肾炎、27例IgA肾病、19例微小病变性肾病、5例轻度系膜增生性肾小球肾炎和6例局灶节段性肾小球硬化。应用间接免疫荧光法检测患者肾组织中PLA2R1抗原。结果41例特发性膜性肾病患者中35例肾组织PLA2R1抗原阳性,阳性率为85.37%。其中PLA2R1沿着肾小球毛细血管襻呈细颗粒状沉积。在V型狼疮性肾炎、乙型肝炎病毒相关性膜性肾病及其他肾小球疾病肾组织中均未发现PLA2R1抗原沉积。特发性膜性肾病PLA2R1阳性患者与PLA2R1阴性患者相比较,年龄、血肌酐、血清白蛋白、24 h尿蛋白定量均无统计学差异(P>0.05)。结论在成人特发性膜性肾病患者肾组织中应用间接免疫荧光法证实PLA2R1抗原的阳性率为85.37%,PLA2R1阳性与阴性患者在临床表现上无统计学差异。
目的:檢測在成人特髮性膜性腎病患者腎組織中M型燐脂酶A2受體1(PLA2R1)抗原的暘性率及其與特髮性膜性腎病關繫。方法選取經腎活檢證實的108例腎小毬疾病患者,其中包括41例特髮性膜性腎病、2例乙型肝炎病毒相關性膜性腎病、8例V型狼瘡腎炎、27例IgA腎病、19例微小病變性腎病、5例輕度繫膜增生性腎小毬腎炎和6例跼竈節段性腎小毬硬化。應用間接免疫熒光法檢測患者腎組織中PLA2R1抗原。結果41例特髮性膜性腎病患者中35例腎組織PLA2R1抗原暘性,暘性率為85.37%。其中PLA2R1沿著腎小毬毛細血管襻呈細顆粒狀沉積。在V型狼瘡性腎炎、乙型肝炎病毒相關性膜性腎病及其他腎小毬疾病腎組織中均未髮現PLA2R1抗原沉積。特髮性膜性腎病PLA2R1暘性患者與PLA2R1陰性患者相比較,年齡、血肌酐、血清白蛋白、24 h尿蛋白定量均無統計學差異(P>0.05)。結論在成人特髮性膜性腎病患者腎組織中應用間接免疫熒光法證實PLA2R1抗原的暘性率為85.37%,PLA2R1暘性與陰性患者在臨床錶現上無統計學差異。
목적:검측재성인특발성막성신병환자신조직중M형린지매A2수체1(PLA2R1)항원적양성솔급기여특발성막성신병관계。방법선취경신활검증실적108례신소구질병환자,기중포괄41례특발성막성신병、2례을형간염병독상관성막성신병、8례V형랑창신염、27례IgA신병、19례미소병변성신병、5례경도계막증생성신소구신염화6례국조절단성신소구경화。응용간접면역형광법검측환자신조직중PLA2R1항원。결과41례특발성막성신병환자중35례신조직PLA2R1항원양성,양성솔위85.37%。기중PLA2R1연착신소구모세혈관반정세과립상침적。재V형랑창성신염、을형간염병독상관성막성신병급기타신소구질병신조직중균미발현PLA2R1항원침적。특발성막성신병PLA2R1양성환자여PLA2R1음성환자상비교,년령、혈기항、혈청백단백、24 h뇨단백정량균무통계학차이(P>0.05)。결론재성인특발성막성신병환자신조직중응용간접면역형광법증실PLA2R1항원적양성솔위85.37%,PLA2R1양성여음성환자재림상표현상무통계학차이。
Objective To investigate the prevalence of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy (IMN) and explore the relationship between PLA2R1 and IMN. Methods A total of 108 adult patients with biopsy-proved glomerular diseases were enrolled in this study, including 41 with IMN, 2 with hepatitis B-associated membranous nephropathy, 8 with V lupus nephritis, 27 with IgA nephropathy, 19 with minimal change nephropathy, 5 with mild mesangial proliferative glomerulonephritis, and 6 with focal segmental glomeruloselerosis (FSGS). Indirect immunofluorescence assay was used to detect PLA2R1 in the biopsy specimens and the clinical variables of the IMN patients were analyzed. Results In 35 of the 41 (85.37%) patients with IMN, PLA2R1 was detected with a fine granular pattern in the subepithelial deposits along the glomerular capillary loops. PLA2R1 antigen was not detected in patients with other glomerulopathies. No significant differences were found in age, serum creatinine, serum albumin, or 24-h urinary protein level between PLA2R1-positive and negative patients with IMN (P>0.05). Conclusion According to our results, 85.37% of adult patients with biopsy-proven IMN are positive for PLA2R1 antigen, which, however, does not contribute to variations of the patients' clinical manifestations.