国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
6期
476-480
,共5页
NALP3%丝裂原活化蛋白激酶%核转录因子κB%活性氧簇
NALP3%絲裂原活化蛋白激酶%覈轉錄因子κB%活性氧簇
NALP3%사렬원활화단백격매%핵전록인자κB%활성양족
NALP3%Mitogen-activated protein kinases%Nuclear factor-κB%Reactive oxygen species
NALP3炎性复合体是机体固有免疫系统的重要成分,能促进caspase-1和IL-1β活化,诱导多种与炎症级联反应相关的细胞因子表达及活化,产生炎症免疫应答反应,与多种自身免疫性疾病及非感染性全身性疾病密切相关.NALP3炎性复合体与许多信号通路有关,本文主要就NALP3炎性复合体与MAPK、核转录因子κB及活性氧簇信号通路之间的关系作一综述.
NALP3炎性複閤體是機體固有免疫繫統的重要成分,能促進caspase-1和IL-1β活化,誘導多種與炎癥級聯反應相關的細胞因子錶達及活化,產生炎癥免疫應答反應,與多種自身免疫性疾病及非感染性全身性疾病密切相關.NALP3炎性複閤體與許多信號通路有關,本文主要就NALP3炎性複閤體與MAPK、覈轉錄因子κB及活性氧簇信號通路之間的關繫作一綜述.
NALP3염성복합체시궤체고유면역계통적중요성분,능촉진caspase-1화IL-1β활화,유도다충여염증급련반응상관적세포인자표체급활화,산생염증면역응답반응,여다충자신면역성질병급비감염성전신성질병밀절상관.NALP3염성복합체여허다신호통로유관,본문주요취NALP3염성복합체여MAPK、핵전록인자κB급활성양족신호통로지간적관계작일종술.
The NALP3 inflammasome,a key component of the innate immune system,facilitates caspase-1 and interleukin-1β processing,induces the expression and activation of cytokines associated with inflammation cascade reaction,causes inflammatory immune response,is closely associated with various autoimmune diseases and non infectious systemic diseases.NALP3 inflammasome has relation with many signal pathways.The relationship between NALP3 inflammasome and mitogen-activated protein kinases,nuclear factor-κB,reactive oxygen species signal pathway will be discussed in this review.
