CAJ | 학술논문

Notch1信号通路是许多细胞信号转导通路的交汇点,不仅在正常组织、细胞的分化、发育过程中起重要作用,而且与一些肿瘤的发生、发展相关,如食管癌、胃癌、宫颈癌、结肠癌、肺癌等.Notch1在非小细胞肺癌中的作用多样.了解Notch1和非小细胞肺癌的关系有利于进一步阐明非小细胞肺癌的发生机制,为非小细胞肺癌的治疗提供一个新的有希望的治疗靶点.
Notch1신호통로시허다세포신호전도통로적교회점,불부재정상조직、세포적분화、발육과정중기중요작용,이차여일사종류적발생、발전상관,여식관암、위암、궁경암、결장암、폐암등.Notch1재비소세포폐암중적작용다양.료해Notch1화비소세포폐암적관계유리우진일보천명비소세포폐암적발생궤제,위비소세포폐암적치료제공일개신적유희망적치료파점.
Notch1 signal pathway is the intersection point of many cell signal transduction pathways,not only plays an important role in the process of differentiation and development of normal tissue and cell,but also is related to occurrence and development of some tumors,such as esophageal cancer,gastric cancer,cervical cancer,colon cancer,lung cancer,etc.Role of Notch1 in non-small cell lung cancer is diverse.To investigate the relationship between Notch1 and non-small cell lung cancer is conducive to further clarify the pathogenesis of non-small cell lung cancer,and provides a new promising therapeutic target for the treatment of non-small cell lung cancer.