国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2015年
6期
432-435
,共4页
切除修复交叉互补基因1%多态性%肺癌%meta分析
切除脩複交扠互補基因1%多態性%肺癌%meta分析
절제수복교차호보기인1%다태성%폐암%meta분석
Excision repair cross completion 1%Polymorphism%Lung cancer%Meta analysis
目的 探讨切除修复交叉互补基因1(ERCC-1)rs3212986位点多态性与肺癌易感性的关系.方法 使用PubMed数据库检索2013年5月以前相关文献,按纳入标准搜索研究ERCC-1rs3212986C/T多态性与肺癌易感性相关的文献,采用STATA软件进行统计分析.结果 共有5 009例肿瘤患者和5 542名对照个体被纳入荟萃分析.分析表明ERCC-1 rs3212986 C/T多态性与肺癌易感性有统计学相关性(等位基因比P=0.043,OR =0.90,95％CI:0.81～0.99).结论 ERCC-1rs3212986C/T多态性与肺癌易感性存在一定的相关性,等位基因T可能会增加肺癌的易感性.
目的 探討切除脩複交扠互補基因1(ERCC-1)rs3212986位點多態性與肺癌易感性的關繫.方法 使用PubMed數據庫檢索2013年5月以前相關文獻,按納入標準搜索研究ERCC-1rs3212986C/T多態性與肺癌易感性相關的文獻,採用STATA軟件進行統計分析.結果 共有5 009例腫瘤患者和5 542名對照箇體被納入薈萃分析.分析錶明ERCC-1 rs3212986 C/T多態性與肺癌易感性有統計學相關性(等位基因比P=0.043,OR =0.90,95％CI:0.81～0.99).結論 ERCC-1rs3212986C/T多態性與肺癌易感性存在一定的相關性,等位基因T可能會增加肺癌的易感性.
목적 탐토절제수복교차호보기인1(ERCC-1)rs3212986위점다태성여폐암역감성적관계.방법 사용PubMed수거고검색2013년5월이전상관문헌,안납입표준수색연구ERCC-1rs3212986C/T다태성여폐암역감성상관적문헌,채용STATA연건진행통계분석.결과 공유5 009례종류환자화5 542명대조개체피납입회췌분석.분석표명ERCC-1 rs3212986 C/T다태성여폐암역감성유통계학상관성(등위기인비P=0.043,OR =0.90,95％CI:0.81～0.99).결론 ERCC-1rs3212986C/T다태성여폐암역감성존재일정적상관성,등위기인T가능회증가폐암적역감성.
Objective To determine the association of excision repair cross completion 1 (ERCC1) rs3212986 C＞T polymorphism and lung cancer risk.Methods Pubmed database was utilized to search the literatures about association of ERCC1 rs3212986 C＞T polymorphism and lung cancer risk.All the statistical analysis was performed by STATA software.Results 5 009 lung cancer cases and 5 542 controls were included in this meta analysis.The results revealed that ERCC-1 rs3212986 polymorphism was statistically associated with lung caner risk (allelic contrast P =0.043,OR =0.90,95％ CI:0.81-0.99).Conclusions ERCC-1 rs3212986 polymorphism is correlated to lung cancer risk,carrying T allele may increase the risk of lung cancer.
