重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
10期
1367-1369
,共3页
吴光平%蒲元芳%田阗%庞勇%曹轲%杨咏%徐波%李媛%谢艳%何敏
吳光平%蒲元芳%田闐%龐勇%曹軻%楊詠%徐波%李媛%謝豔%何敏
오광평%포원방%전전%방용%조가%양영%서파%리원%사염%하민
超声,高强聚焦,经肠%肝肿瘤%能效因子%无水乙醇注射术
超聲,高彊聚焦,經腸%肝腫瘤%能效因子%無水乙醇註射術
초성,고강취초,경장%간종류%능효인자%무수을순주사술
ultrasound,high-intensity focused,transrectal%liver neoplasms%energy efficiency factor%percutaneous ethanol in-jection
目的：探讨在镇静镇痛下行无水乙醇注射术（PEI），能否提高高强度聚焦超声（HIFU）治疗不能手术切除的中晚期原发性肝癌（PCL）的能量沉积及其治疗效率。方法将临床确诊的不能手术切除的中晚期 PCL 患者36例分为 PEI 联合 HI-FU 治疗组（联合组，n＝23）和单纯 HIFU 治疗组（HIFU 组，n＝13）；联合组于消融前30 min 向瘤体内注入99．70％无水乙醇与碘化油（9∶1）混合液10 mL，HIFU 组以0．9％生理盐水10 mL 替代，比较两组患者消融的能效因子（EEF）及辐照时间。结果联合组、HIFU 组消融 EEF 分别为（13．82±4．26）、（25．63±6．31）J／ mm3，联合组明显低于 HIFU 组（P ＜0．05）；辐照时间分别为（1468．28±253．21）、（2352．56±463．34）s；联合组辐照时间明显缩短（P ＜0．05）。结论PEI 能够增强 HIFU 消融能量沉积，能够提高 HIFU 治疗不能手术切除的 PCL 的治疗效率。
目的：探討在鎮靜鎮痛下行無水乙醇註射術（PEI），能否提高高彊度聚焦超聲（HIFU）治療不能手術切除的中晚期原髮性肝癌（PCL）的能量沉積及其治療效率。方法將臨床確診的不能手術切除的中晚期 PCL 患者36例分為 PEI 聯閤 HI-FU 治療組（聯閤組，n＝23）和單純 HIFU 治療組（HIFU 組，n＝13）；聯閤組于消融前30 min 嚮瘤體內註入99．70％無水乙醇與碘化油（9∶1）混閤液10 mL，HIFU 組以0．9％生理鹽水10 mL 替代，比較兩組患者消融的能效因子（EEF）及輻照時間。結果聯閤組、HIFU 組消融 EEF 分彆為（13．82±4．26）、（25．63±6．31）J／ mm3，聯閤組明顯低于 HIFU 組（P ＜0．05）；輻照時間分彆為（1468．28±253．21）、（2352．56±463．34）s；聯閤組輻照時間明顯縮短（P ＜0．05）。結論PEI 能夠增彊 HIFU 消融能量沉積，能夠提高 HIFU 治療不能手術切除的 PCL 的治療效率。
목적：탐토재진정진통하행무수을순주사술（PEI），능부제고고강도취초초성（HIFU）치료불능수술절제적중만기원발성간암（PCL）적능량침적급기치료효솔。방법장림상학진적불능수술절제적중만기 PCL 환자36례분위 PEI 연합 HI-FU 치료조（연합조，n＝23）화단순 HIFU 치료조（HIFU 조，n＝13）；연합조우소융전30 min 향류체내주입99．70％무수을순여전화유（9∶1）혼합액10 mL，HIFU 조이0．9％생리염수10 mL 체대，비교량조환자소융적능효인자（EEF）급복조시간。결과연합조、HIFU 조소융 EEF 분별위（13．82±4．26）、（25．63±6．31）J／ mm3，연합조명현저우 HIFU 조（P ＜0．05）；복조시간분별위（1468．28±253．21）、（2352．56±463．34）s；연합조복조시간명현축단（P ＜0．05）。결론PEI 능구증강 HIFU 소융능량침적，능구제고 HIFU 치료불능수술절제적 PCL 적치료효솔。
Objective To investigate whether the percutaneous ethanol injection (PEI)under sedation and analgesia can in-crease the energy deposition and curative efficiency of the high intensity focused ultrsound(HIFU)in treating unresectable middle and advanced stages of primary liver cancer.Methods Thirty-six cases of clinically diagnosed unresectable middle and advanced sta-ges of primary liver cancer were randomly divided into the PEI+ HIFU group(combination group,n = 23)and the simple HIFU group (HIFU group,n=13);10mL of the mixture of 99.7% ethanol and iodized oil (9:1)was given by intratumoral injection at 30 min before ablation in the PEI+HIFU group,while 0.9% physiological saline 10mL was replaced in the simple HIFU group.The ablation energy efficiency factor(EEF)and irradiation time were compared between the two groups.Results The ablation EEF in the PEI+HIFU group and the simple HIFU group were (13.82+4.26)J/mm3 and (25.63+6.31)J/mm3 respectively,the PEI+HIFU group was significantly lower than the simple HIFU group (P <0.05);the irradiation time were (1 468.28+253.21)s and (2 352.56+463.34)s respectively;which in the PEI+ HIFU group was significantly shortened (P <0.05).Conclusion PEI can enhance the HIFU ablation energy deposition and improve the efficiency of HIFU for treating unresectable primary liver cancer.
