CAJ | 학술논문

目的：探讨影响雌激素受体（ ER）阳性乳腺癌患者预后的因素。方法收集2006年1月至2009年11月诊治的229例ER阳性乳腺癌患者的临床和随访资料，分析其临床病理参数中与预后相关的因素。将发病年龄、月经状况、肿瘤大小、淋巴结转移率（ LNR）、PR表达、Her?2表达、组织学分级、新辅助化疗及放疗等因素进行Kaplan?Meier单因素和Cox回归多因素生存分析。结果获随访的223例患者的复发率为15?70％。 Cox模型多因素生存分析显示：肿瘤大小、LNR、Her?2表达及PR表达均为影响ER阳性患者接受内分泌治疗后无复发生存的独立因素（ P＜0?05）。结论肿瘤越大、Her?2过表达、PR阴性及LNR较高是ER阳性乳腺癌复发转移的独立危险因素。
목적：탐토영향자격소수체（ ER）양성유선암환자예후적인소。방법수집2006년1월지2009년11월진치적229례ER양성유선암환자적림상화수방자료，분석기림상병리삼수중여예후상관적인소。장발병년령、월경상황、종류대소、림파결전이솔（ LNR）、PR표체、Her?2표체、조직학분급、신보조화료급방료등인소진행Kaplan?Meier단인소화Cox회귀다인소생존분석。결과획수방적223례환자적복발솔위15?70％。 Cox모형다인소생존분석현시：종류대소、LNR、Her?2표체급PR표체균위영향ER양성환자접수내분비치료후무복발생존적독립인소（ P＜0?05）。결론종류월대、Her?2과표체、PR음성급LNR교고시ER양성유선암복발전이적독립위험인소。
Objective To investigate the related factors for prognosis of estrogen receptor( ER)?positive breast cancer. Meth?ods The clinical and pathological data of 229 patients with ER?positive breast cancer from Jan 2006 to Nov 2009 were collected. The onset of age, menstrual status, tumor size, tumor grade, lymph node ratio( LNR) , expression patterns of PR and Her?2, neoadjuvant chemotherapy and radiotherapy were analyzed by Kaplan?Meier survival plots and multivariable Cox hazard regression analysis to identify prognostic factors for survival. Results In this retrospective analysis,15?70% of 223 patients who had completed the follow?up suffered from local recurrence or metastasis. The Cox regression revealed that the tumor size, LNR, expression patterns of PR and Her?2 affected the recurrence?free survival after the endocrine therapy of breast cancer. Conclusion Large size of tumor, high LNR, over?expression of Her?2 and loss of PR are risk factors for recurrence/metastasis of ER?positive breast cancer.