CAJ | 학술논문

20世纪20年代，德国生化学家瓦伯格发现即使在有氧条件下，肿瘤细胞也是通过糖酵解的方式获得生存必需的能量，这一现象被称为瓦伯格效应。然而，后续越来越多的研究发现并非所有的肿瘤中均存在瓦伯格效应，或者说并非所有的肿瘤细胞均存在瓦伯格效应。肿瘤细胞的代谢存在明显的多样性，部分细胞表现为糖酵解方式产能，另外一部分细胞表现为氧化磷酸化方式产能。两类细胞能够通过乳酸穿梭机制相互协调，和谐共处，即代谢共生。本文将就代谢共生的物质基础和细胞间的代谢共生现象，以及代谢共生对肿瘤细胞特性的影响及临床意义方面作一综述。希望通过对代谢共生的全面认识为设计全新而高效的治疗策略提供有益的帮助。
20세기20년대，덕국생화학가와백격발현즉사재유양조건하，종류세포야시통과당효해적방식획득생존필수적능량，저일현상피칭위와백격효응。연이，후속월래월다적연구발현병비소유적종류중균존재와백격효응，혹자설병비소유적종류세포균존재와백격효응。종류세포적대사존재명현적다양성，부분세포표현위당효해방식산능，령외일부분세포표현위양화린산화방식산능。량류세포능구통과유산천사궤제상호협조，화해공처，즉대사공생。본문장취대사공생적물질기출화세포간적대사공생현상，이급대사공생대종류세포특성적영향급림상의의방면작일종술。희망통과대대사공생적전면인식위설계전신이고효적치료책략제공유익적방조。
In the 1920s, German biochemist Warburg found that tumor cells used glycolysis for energy generation to maintain survival even under aerobic conditions, a phenomenon known as the Warburg effect. However, a growing number of studies have found that not all kinds of tumor showed the Warburg effect, or not all of tumor cells used the Warburg effect for energy generation. There is the diversity of metabolism in tumor cells. Some cells used glycolysis for energy production, but other cells used oxidative phosphoryla?tion for energy production. Two types of cells can mutually coordinate and coexist with each other through lactic acid shuttle system, which is named metabolic symbiosis. This review will discuss the material basis of metabolic symbiosis and symbiosis phenomenon a?mong cells in tumor. This review will also discuss the effect by metabolic symbiosis on characteristics of tumor cells and the clinical sig?nificance of metabolic symbiosis. A fully understanding of metabolic symbiosis in tumor cells is helpful for designing new and effective anti?cancer treatment strategies.