CAJ | 학술논문

Bmi－1属于核染色质调控因子多梳基因家族，是与干细胞和肿瘤干细胞相关基因。直接参与细胞周期、凋亡和衰老的调控，在维持干细胞的自我更新及多向分化方面起重要作用；在多数肿瘤中表达失调，并且与恶性肿瘤的侵袭、转移和预后显著相关。它为恶性肿瘤患者的早期诊断、肿瘤的治疗和生存率的预测提供了一条重要途径，鉴于 Bmi－1在人类肿瘤中的重要作用，今后应着重开展关于Bmi－1与各种肿瘤干细胞关系的研究。
Bmi－1속우핵염색질조공인자다소기인가족，시여간세포화종류간세포상관기인。직접삼여세포주기、조망화쇠로적조공，재유지간세포적자아경신급다향분화방면기중요작용；재다수종류중표체실조，병차여악성종류적침습、전이화예후현저상관。타위악성종류환자적조기진단、종류적치료화생존솔적예측제공료일조중요도경，감우 Bmi－1재인류종류중적중요작용，금후응착중개전관우Bmi－1여각충종류간세포관계적연구。
Bmi-1(Blymphoma Mo-MLV insertion region1homolog) is a member of the chromatin regula-tor polycomb group of genes( PcGs) ,which is a stem cell factor implicated in many cancers .Bmi-1 directly involves in the regulation of cell cycle,apoptosis and senescence.It plays an important role in maintaining the stem cell self-renewal and multi-differentiation.The expression of the Bmi-1 gets imbalanced in many caners, and it correlates with the cancer invasion ,metastasis and prognosis significantly .Bmi-1 gene offers a potential way for early diagnosis,treatment of cancer and prediction of survival rate in cancer patients.Given the important role of Bmi-1 in human tumors,research on the relationship between Bmi-1 and cancer stem cells should be focused on.