CAJ | 학술논문

人类表皮生长因子受体（ Her）是乳腺癌发生、发展及预后的重要生物学标志物之一，该家族由Her－1、Her－2、Her－3和Her－4组成，各成员之间具有高度同源性，均具有酪氨酸激酶活性。该家族成员在乳腺癌组织中的表达和作用不同，有成员可促进乳腺癌的发展，也有成员可提高药物敏感性。因此，研究各成员的生物学特性、功能及其与乳腺癌的关系将会为乳腺癌判断、治疗以及预后提供帮助。
인류표피생장인자수체（ Her）시유선암발생、발전급예후적중요생물학표지물지일，해가족유Her－1、Her－2、Her－3화Her－4조성，각성원지간구유고도동원성，균구유락안산격매활성。해가족성원재유선암조직중적표체화작용불동，유성원가촉진유선암적발전，야유성원가제고약물민감성。인차，연구각성원적생물학특성、공능급기여유선암적관계장회위유선암판단、치료이급예후제공방조。
Human epidermal growth factor receptor ( Her) is one of the important biological markers in the carcinogenesis,progression and prognosis of breast cancer,the family consists of Her-1,Her-2,Her-3 and Her-4,and all of the members are highly homologous and have the activity of tyrosine kinase .But each of them has different expression and function in human breast cancer tissue ,some can promote the development of breast cancer,while the others can improve the drug sensitivity.Therefore,study on the biological charac-teristics and function of those members ,as well as their relationship with breast cancer is helpful for the diag-nosis,treatment and prognosis of breast cancer.