CAJ | 학술논문

目的：探讨老年慢性淋巴细胞白血病（CLL）的临床特点。方法对解放军总医院1999年6月至2013年6月收治的12例＞60岁的CLL患者的临床资料进行回顾性分析。结果12例患者中初诊时中位年龄75.5岁。所有患者均有合并症，其中以高血压最常见，有的（3/12）甚至合并第二肿瘤。共9例患者接受了个体化的治疗方案，5例进展（PD，例1、2、3、10、12总生存期分别为107个月、64个月、174个月、69个月、4个月），2例完全缓解（CR），1例部分缓解（PR），1例稳定（SD）。4例死于CLL进展，1例死于感染，3例死于第二肿瘤。结论老年CLL临床症状不典型，合并基础疾病多，因个体差异大，应根据患者不同情况采取个体化治疗。
목적：탐토노년만성림파세포백혈병（CLL）적림상특점。방법대해방군총의원1999년6월지2013년6월수치적12례＞60세적CLL환자적림상자료진행회고성분석。결과12례환자중초진시중위년령75.5세。소유환자균유합병증，기중이고혈압최상견，유적（3/12）심지합병제이종류。공9례환자접수료개체화적치료방안，5례진전（PD，례1、2、3、10、12총생존기분별위107개월、64개월、174개월、69개월、4개월），2례완전완해（CR），1례부분완해（PR），1례은정（SD）。4례사우CLL진전，1례사우감염，3례사우제이종류。결론노년CLL림상증상불전형，합병기출질병다，인개체차이대，응근거환자불동정황채취개체화치료。
Objective To investigate the clinical features of chronic lymphocytic leukemia (CLL) in the elderly. Methods A total of 12 elderly patients (over 60 years old) with CLL admitted in our hospital from June 1999 to June 2013 were enrolled in this study and retrospectively analyzed. Results The mean age was 75.5 years in the cohort. All patients had suffered from underlying diseases, and hypertension was the most common one. And some of them (3/12) even complicated with the secondary tumor. Nine cases received individualized treatments. The results showed that 5 patients suffered progressive disease (PD, Sample 1, 2, 3, 10 and 12 had the total survival time of 107, 64, 174, 69 and 4 months, respectively), 2 patients achieved complete remission (CR), 1 patient achieved partial remission (PR), and 1 patient reported stable disease (SD). Four patients died of progressive CLL, 1 of infection, and the other 3 of the secondary tumor. Conclusion Elderly CLL has atypical symptoms and many underlying diseases. Treatment should be individualized based on patient’s status.