CAJ | 학술논문

目的：在猪房间隔缺损动物模型上评价改良的封堵器有效性、安全性和相容性。方法选用西藏小型猪5头，利用房间隔穿刺结合囊扩张的方法建立房间隔缺损（ atrial spetal defect， ASD）猪，用改良的封堵器进行房间隔封堵术，术后进行超声心动图、大体解剖、电镜扫描和光镜观察。结果5只猪均成功建立了ASD模型并进行封堵术成功，超声心动图观察显示封堵器良好，位置固定，心腔和心肺功能正常。3个月后封堵器与房间隔组织紧密嵌合，表面覆盖一层较厚的光滑的白色组织，电镜下观察到大量心肌纤维，未发现内皮细胞。结论改良的ASD封堵器操作简便、安全性好，具有良好的生物相容性。
목적：재저방간격결손동물모형상평개개량적봉도기유효성、안전성화상용성。방법선용서장소형저5두，이용방간격천자결합낭확장적방법건립방간격결손（ atrial spetal defect， ASD）저，용개량적봉도기진행방간격봉도술，술후진행초성심동도、대체해부、전경소묘화광경관찰。결과5지저균성공건립료ASD모형병진행봉도술성공，초성심동도관찰현시봉도기량호，위치고정，심강화심폐공능정상。3개월후봉도기여방간격조직긴밀감합，표면복개일층교후적광활적백색조직，전경하관찰도대량심기섬유，미발현내피세포。결론개량적ASD봉도기조작간편、안전성호，구유량호적생물상용성。
Objective To evaluate the efficacy, safety and compatibility of a new type of atrial septal defect ( ASD) occluder in atrial spetal defect mini-pigs model.Methods Five Tibet mini-pigs were selected as the ASD models which were established by the combination of atrial septal puncture and balloon dilation.Then the new type occluder was implanted for the therapy of ASD.Transthoracic echocardiography with color Doppler was used in all animals during closure and in follow up examinations.The animals were killed at 3 months after occlusion for electron microscopical observation and microscopic examination.Result The ASD models had been created in five piglets successfully without complication, all of whom were implanted successfully with the new device without shunts.Postmortem and microscopic examination of the 5 specimens 3 months after placement showed complete.Conclusion Transcatheter ASD occlusion with new type ASD occluder is safe,feasible and effective.This occlusion can repair the atrial septal defect successfully.