CAJ | 학술논문

目的：探讨高尿酸血症患者血清炎症因子水平与颈动脉粥样硬化的关系。方法选取2011年2月~2014年2月本院内科收治的68例高尿酸血症患者及56例健康者分别作为实验组和对照组，测定两组的血尿酸(SUA)、白细胞介素-8(IL-8)、细胞间黏附分子-1(ICAM-1)、超敏-C反应蛋白(hs-CRP)及颈动脉内中膜厚度(IMT)，分析高尿酸血症患者血清炎症因子水平与颈动脉粥样硬化程度的关系。结果实验组血清SUA、IL-8、ICAM-1、hs-CRP水平较对照组明显升高，且IMT也明显高于对照组，差异有统计学意义(P<0.05或P<0.01)。实验组颈动脉正常、颈动脉增厚、颈动脉斑块、颈动脉狭窄比例高于对照组，较差异有统计学意义(P<0.05或P<0.01)。高尿酸血症患者的血清SUA、IL-8、ICAM-1、hs-CRP水平随着患者颈动脉粥样硬化程度(IMT)的加重而上升。结论高尿酸血症患者的血清SUA、IL-8、ICAM-1、hs-CRP水平及颈动脉IMT明显升高，SUA、IL-8、ICAM-1、hs-CRP可为患者颈动脉粥样硬化临床治疗提供帮助。
목적：탐토고뇨산혈증환자혈청염증인자수평여경동맥죽양경화적관계。방법선취2011년2월~2014년2월본원내과수치적68례고뇨산혈증환자급56례건강자분별작위실험조화대조조，측정량조적혈뇨산(SUA)、백세포개소-8(IL-8)、세포간점부분자-1(ICAM-1)、초민-C반응단백(hs-CRP)급경동맥내중막후도(IMT)，분석고뇨산혈증환자혈청염증인자수평여경동맥죽양경화정도적관계。결과실험조혈청SUA、IL-8、ICAM-1、hs-CRP수평교대조조명현승고，차IMT야명현고우대조조，차이유통계학의의(P<0.05혹P<0.01)。실험조경동맥정상、경동맥증후、경동맥반괴、경동맥협착비례고우대조조，교차이유통계학의의(P<0.05혹P<0.01)。고뇨산혈증환자적혈청SUA、IL-8、ICAM-1、hs-CRP수평수착환자경동맥죽양경화정도(IMT)적가중이상승。결론고뇨산혈증환자적혈청SUA、IL-8、ICAM-1、hs-CRP수평급경동맥IMT명현승고，SUA、IL-8、ICAM-1、hs-CRP가위환자경동맥죽양경화림상치료제공방조。
Objective To explore the relationship between serum inflammatory cytokines level and carotid artery atheroscle-rosis in patients with hyperuricemia. Methods 68 patients with hyperuricemia treated in our hospital from February 2011 to February 2014 and 56 healthy subjects were selected as experimental group and control group.Serum uric acid (SUA),interleukin-8 (IL-8),intracellular adhesion molecule 1 (ICAM-1) and high-sensitivity C-reactive protein (hs-CRP) of two groups was tested,and the relationship between serum inflammatory cytokines level and carotid artery atherosclerosis was analyzed. Results Levels of SUA,IL-8,ICAM-1,hs-CRP and IMT in experimental group was higher than that in control group,the difference was significant (P<0.05 or P<0.01).The proportion of normal carotid artery, thickening of carotid artery,carotid artery plaque and carotid artery stenosis in experimental group was higher than that in control group,the difference was significant (P<0.05 or P<0.01).The level of SUA,IL-8,ICAM-1,hs-CRP in patients with hyperuricemia increased with the degree of carotid atherosclerosis of patients. Conclusion Levels of SUA,IL-8, ICAM-1,hs-CRP and IMT increases significantly in patients with hyperuricemia,and SUA,IL-8,ICAM-1,hs-CRP can provide help for clinical treatment of carotid artery atherosclerosis.