CAJ | 학술논문

目的：分析介入治疗中血栓抽吸联合替罗非班内注射对急性心肌梗死患者预后情况的影响。方法选择2013年11月~2014年11月在本院接受介入治疗的急性心肌梗死患者108例纳入研究，按照随机数字表法将其分为观察组和对照组各54例，观察组接受介入治疗中血栓抽吸联合替罗非班内注射，对照组接受常规介入治疗，比较两组患者的血清心肌酶谱、心功能指标水平及近期预后。结果介入治疗后，观察组患者的血清高敏心肌肌钙蛋白(hs-cTnT)、肌酸激酶同工酶(CK-MB)水平明显低于对照组(P<0.05)；观察组血清左室射血分数(LVEF)、左室舒张末期内径(LVEDd)水平明显低于对照组(P<0.05)；介入治疗后30 d，观察组患者的再发心绞痛、急性心力衰竭、再发急性心肌梗死、死亡等不良事件发生率均明显低于对照组(P<0.05)。结论介入治疗中血栓抽吸联合替罗非班内注射有助于优化急性心肌梗死患者的心肌酶谱及心功能指标，改善近期预后。
목적：분석개입치료중혈전추흡연합체라비반내주사대급성심기경사환자예후정황적영향。방법선택2013년11월~2014년11월재본원접수개입치료적급성심기경사환자108례납입연구，안조수궤수자표법장기분위관찰조화대조조각54례，관찰조접수개입치료중혈전추흡연합체라비반내주사，대조조접수상규개입치료，비교량조환자적혈청심기매보、심공능지표수평급근기예후。결과개입치료후，관찰조환자적혈청고민심기기개단백(hs-cTnT)、기산격매동공매(CK-MB)수평명현저우대조조(P<0.05)；관찰조혈청좌실사혈분수(LVEF)、좌실서장말기내경(LVEDd)수평명현저우대조조(P<0.05)；개입치료후30 d，관찰조환자적재발심교통、급성심력쇠갈、재발급성심기경사、사망등불량사건발생솔균명현저우대조조(P<0.05)。결론개입치료중혈전추흡연합체라비반내주사유조우우화급성심기경사환자적심기매보급심공능지표，개선근기예후。
Objective To analyze the influence of thrombus aspiration combined with tirofiban injection during inter-ventional therapy on prognosis of acute myocardial infarction (AMI). Methods 108 patients with AMI accepted percuta-neous coronary intervention (PCI) therapy in our hospital from November 2013 to November 2014 were selected and even-ly divided into observation group and control group by random number table.In observation group,patients were treated by thrombus aspiration combined with internal injection of tirofiban during interventional therapy,while conventional in-terventional therapy was provided to control group.Serum myocardial enzymes,indexes of cardiac function,and recent prognosis between the two groups was compared. Results After PCI therapy,values of serum hs-cTnT and CK-MB of observation group was lower than that of control group (P<0.05).Values of serum left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDd) in observation group was lower than that in control group (P<0.05).After 30-day PCI therapy,the incidence of adverse events like recurrence of angina,acute cardiac failure,re-currence of AMI,and death in observation group was lower than that in control group (P<0.05). Conclusion Thrombus aspiration combined with internal injection of tirofiban during interventional therapy is beneficial to optimize myocar-dial enzyme and cardiac function in patients with AMI and improve recent prognosis.