CAJ | 학술논문

虽然线虫只是代表了一类简单的生物体，但是线虫在现代生物医学研究，尤其是药物靶点研究方面具有巨大的潜在应用价值。其功能完善的细胞结构、与其他高级生物的保守性使得线虫成为一个操作简单、经济有效的高通量体内研究模型。本文总结了模式生物线虫在药物活性评价中的应用。初步探讨了线虫在药物复杂体系活性评价的可行性，以及线虫为从整体水平观察和研究中药复方的药效及机制的前景。
수연선충지시대표료일류간단적생물체，단시선충재현대생물의학연구，우기시약물파점연구방면구유거대적잠재응용개치。기공능완선적세포결구、여기타고급생물적보수성사득선충성위일개조작간단、경제유효적고통량체내연구모형。본문총결료모식생물선충재약물활성평개중적응용。초보탐토료선충재약물복잡체계활성평개적가행성，이급선충위종정체수평관찰화연구중약복방적약효급궤제적전경。
Caenorhabditis elegans (C.elegans), has developed into an useful model for biomedical research, particularly in the targets of novel drugs and the related mechanism.C.elegans, combining with cost-effective cultivation, simple biological structure, make for high-throughput screenings in vivo model.In this review, we explore the feasibility of C.elegans in drug activity evaluation of complex systems.Because of the body independence of C.elegans, it provided good platform for the efficacy and mechanism of research on new drugs as well as Chinese herbal extract in vivo, showing a good prospect.