CAJ | 학술논문

目的：比较强化胰岛素治疗与常规胰岛素治疗两种方法在治疗重型颅脑损伤患者上的预后差异。方法以2012年1月至2014年6月在我院进行治疗的重型颅脑外伤且合并应激性高血糖的116例患者为研究对象，按病情、年龄、性别等因素配对分成两组，将应用强化胰岛素治疗的58名患者为实验组，将常规胰岛素治疗的58例患者为对照组，并以死亡率、神经功能恢复情况、院内感染率、低血糖发生率为指标分析两组患者的预后差异。结果实验组和对照组两组死亡率差别无统计学意义，但实验组院内感染发生率低于对照组，实验组神经功能恢复情况优于对照组，实验组低血糖发生率高于对照组。结论强化胰岛素治疗能降低重型颅脑损伤患者院内感染发生率，并利于患者神经功能恢复，但需警惕其可能诱发患者低血糖的风险。
목적：비교강화이도소치료여상규이도소치료량충방법재치료중형로뇌손상환자상적예후차이。방법이2012년1월지2014년6월재아원진행치료적중형로뇌외상차합병응격성고혈당적116례환자위연구대상，안병정、년령、성별등인소배대분성량조，장응용강화이도소치료적58명환자위실험조，장상규이도소치료적58례환자위대조조，병이사망솔、신경공능회복정황、원내감염솔、저혈당발생솔위지표분석량조환자적예후차이。결과실험조화대조조량조사망솔차별무통계학의의，단실험조원내감염발생솔저우대조조，실험조신경공능회복정황우우대조조，실험조저혈당발생솔고우대조조。결론강화이도소치료능강저중형로뇌손상환자원내감염발생솔，병리우환자신경공능회복，단수경척기가능유발환자저혈당적풍험。
Objective To compare the outcomes between intensive insulin therapy (IIT) and conventional insulin therapy (CIT) in patients with severe traumatic brain injury. Methods A retrospective study was preformed , including 116 severe traumatic brain injury patients complicated with stress hyperglycemia from our hospital during Jan 2012 to June 2014. The patients were paired and divided into two groups according to the condition , age and gender. The patients in group A were treated with IIT regimen and those in group B received CIT. The mortality, neurological function, nosocomial infection and hypoglycemia were recorded , analyzed and cpmpared between two groups. Results There was no statistical significance of the mortality between group A and B. Group A was associated with a lower incidence of nosocomial infection than group B. The neurological functional recovery of group A was better than that of group B. The hypoglycemia risk of group A was higher than that of group B. Conclusion Intensive insulin therapy can reduce nosocomial infection and have benefit in the neurological recover, but takes a risk of hypoglycemia.