CAJ | 학술논문

目的：探讨膝关节滑液中 P 物质水平在骨性关节炎（OA）发病机制中的作用及与OA 患者病情严重程度、疼痛程度的相关性。方法2012年2月～2014年4月选取在我医院住院治疗或者门诊治疗的膝 OA 患者212例，诊断均符合美国风湿病学会（ARA）制定的 OA 分类标准。骨关节的严重程度采用 Legusue 分级系统评估进行评估并分组。轻度组（ A1）75例，中度组（A2）87例，重度组（A3）50例。疼痛严重程度按WOMAC）疼痛评分系统评估。另选择115例来自本院健康体检者作为正常对照组。采用竞争性酶联免疫吸附试验分别测定滑液中 P 物质水平。结果滑液中P物质水平与骨关节炎患者WOMAC 疼痛评分正相关（r＝0．265，P＜0．05）。滑液中P物质水平与 Legusue 等级之间正相关（r＝0．785，P＜0．05）。结论关节液中 P 物质的变化可作为OA 病情活动的监测指标之一。
목적：탐토슬관절활액중 P 물질수평재골성관절염（OA）발병궤제중적작용급여OA 환자병정엄중정도、동통정도적상관성。방법2012년2월～2014년4월선취재아의원주원치료혹자문진치료적슬 OA 환자212례，진단균부합미국풍습병학회（ARA）제정적 OA 분류표준。골관절적엄중정도채용 Legusue 분급계통평고진행평고병분조。경도조（ A1）75례，중도조（A2）87례，중도조（A3）50례。동통엄중정도안WOMAC）동통평분계통평고。령선택115례래자본원건강체검자작위정상대조조。채용경쟁성매련면역흡부시험분별측정활액중 P 물질수평。결과활액중P물질수평여골관절염환자WOMAC 동통평분정상관（r＝0．265，P＜0．05）。활액중P물질수평여 Legusue 등급지간정상관（r＝0．785，P＜0．05）。결론관절액중 P 물질적변화가작위OA 병정활동적감측지표지일。
Objective To evaluate the relationship between Substance P levels in the synovial tissue of the human knee joint and the severity of progression in patients with knee (osteoarthritis, OA) OA. Methods A total of 212 OA patients and 115 controls were enrolled in the study (control group). The symptomatic severity of OA was assessed by the Legusue grading system. The OA group was divided into 3 groups, Mild OA group (A1, n=57), Mediate OA group (A2, n=87), and Severe group (A3, n=50). The severity of pain was assessed by Western Ontario McMaster University Osteoarthritis Index (WOMAC). Synovia Substance P levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The levels Substance P in the synovial tissue were significantly higher in OA patients compared with controls. Substance P levels were positively correlated with WOMAC-pain scores (r=0.265, P<0.05) and Legusue grades (r=0.785, P<0.05) in OA patients. Conclusion The raised substance P levels might act as an important indication in the pathogenesis of OA.