临床儿科杂志
臨床兒科雜誌
림상인과잡지
2015年
4期
326-329
,共4页
胡方启%程贤高%丁丹%李宗光
鬍方啟%程賢高%丁丹%李宗光
호방계%정현고%정단%리종광
脓毒症%血培养%细菌感染%降钙素原%儿童
膿毒癥%血培養%細菌感染%降鈣素原%兒童
농독증%혈배양%세균감염%강개소원%인동
sepsis%blood culture%bacterial infection%procalcitonin%child
目的：探讨降钙素原(PCT)在判断细菌感染及其种类中的作用。方法回顾性分析2010年1月至2014年6月确诊为脓毒症的253例患儿的血培养结果与其PCT水平的相关性。结果253例脓毒症患儿中，血培养阳性124例，阳性率49.01%；其中G+细菌感染71例(28.06%)，G－细菌感染53例(20.95%)。253例患儿PCT中位水平为1.6(0.4~4.5)ng/ml，其中低(0.05~0.5 ng/ml)、中(~2 ng/ml)、高(~10 ng/ml)、极高组(~300 ng/ml)分别为86例、55例、75例、37例。不同PCT水平组间细菌培养阳性率的差异有统计学意义(χ2=69.14，P<0.01)，PCT低水平组细菌培养阳性率最低，其他三组阳性率均高于60%。不同PCT水平组间G+和G－菌检出率的差异有统计学意义(P均<0.01)，其中，PCT高水平组G+菌检出率最高，而PCT极高水平组G－菌检出率最高。结论 PCT对于判断儿童脓毒症是否为细菌感染有一定指导作用，其水平异常升高可考虑革兰阴性细菌感染。
目的：探討降鈣素原(PCT)在判斷細菌感染及其種類中的作用。方法迴顧性分析2010年1月至2014年6月確診為膿毒癥的253例患兒的血培養結果與其PCT水平的相關性。結果253例膿毒癥患兒中，血培養暘性124例，暘性率49.01%；其中G+細菌感染71例(28.06%)，G－細菌感染53例(20.95%)。253例患兒PCT中位水平為1.6(0.4~4.5)ng/ml，其中低(0.05~0.5 ng/ml)、中(~2 ng/ml)、高(~10 ng/ml)、極高組(~300 ng/ml)分彆為86例、55例、75例、37例。不同PCT水平組間細菌培養暘性率的差異有統計學意義(χ2=69.14，P<0.01)，PCT低水平組細菌培養暘性率最低，其他三組暘性率均高于60%。不同PCT水平組間G+和G－菌檢齣率的差異有統計學意義(P均<0.01)，其中，PCT高水平組G+菌檢齣率最高，而PCT極高水平組G－菌檢齣率最高。結論 PCT對于判斷兒童膿毒癥是否為細菌感染有一定指導作用，其水平異常升高可攷慮革蘭陰性細菌感染。
목적：탐토강개소원(PCT)재판단세균감염급기충류중적작용。방법회고성분석2010년1월지2014년6월학진위농독증적253례환인적혈배양결과여기PCT수평적상관성。결과253례농독증환인중，혈배양양성124례，양성솔49.01%；기중G+세균감염71례(28.06%)，G－세균감염53례(20.95%)。253례환인PCT중위수평위1.6(0.4~4.5)ng/ml，기중저(0.05~0.5 ng/ml)、중(~2 ng/ml)、고(~10 ng/ml)、겁고조(~300 ng/ml)분별위86례、55례、75례、37례。불동PCT수평조간세균배양양성솔적차이유통계학의의(χ2=69.14，P<0.01)，PCT저수평조세균배양양성솔최저，기타삼조양성솔균고우60%。불동PCT수평조간G+화G－균검출솔적차이유통계학의의(P균<0.01)，기중，PCT고수평조G+균검출솔최고，이PCT겁고수평조G－균검출솔최고。결론 PCT대우판단인동농독증시부위세균감염유일정지도작용，기수평이상승고가고필혁란음성세균감염。
ObjectiveTo explore the roles of procalcitonin in differentiating bacterial infection from other inlfammatory processes and identifying bacterial species.MethodsThe blood culture results of 253 hospitalized children diagnosed with sepsis from January 2010 to June 2014 were analyzed retrospectively and its relationship with PCT was also analyzed. ResultsIn 253 children with sepsis, the blood culture results of 124 children showed positive (49.01%). There were 71 (28.06%) cases of Gram-positive infection and 53 (20.95%) cases of Gram-negative infection. The median level of PCT in 253 patients was 1.6 (0.4-4.5) ng/ml. According to the PCT levels, all patients were divided into low level group (0.05-0.5 ng/ml,n=86), middle level group (0.5-2.0 ng/ml,n=55), high level group (2.0-10 ng/ml,n=75) and extremely high level group (10-300 ng/ml,n=37). The positive rates of bacterial culture were signiifcantly different among different levels of PCT (χ2=69.14,P<0.01). In low lev-el group the positive rate of bacterial culture was the lowest and in other three groups the positive rate was all above 60%. The detection rate of Gram-positive and Gram-negative bacteria was signiifcantly different among different levels of PCT (P<0.01). In high level group the detection rate of Gram-positive bacteria was the highest while in extremely high level group the rate of Gram-negative bacteria was the highest.ConclusionsThe level of PCT is helpful for the differentiation of bacterial infection from other inlfammatory processes in children with sepsis and abnormally elevated PCT level may indicates Gram-negative infection.
