CAJ | 학술논문

转录因子GATA6属于GATA转录因子家族，具有2个保守的锌指结构域。它不仅存在于胚胎组织，并且对心脏、肺和胰腺中细胞功能的维持起重要作用。该文对转录因子G ATA 6在心脏发育以及先天性房间隔缺损中的作用作一综述，探讨其对人类房间隔缺损疾病诊断和治疗的价值。
전록인자GATA6속우GATA전록인자가족，구유2개보수적자지결구역。타불부존재우배태조직，병차대심장、폐화이선중세포공능적유지기중요작용。해문대전록인자G ATA 6재심장발육이급선천성방간격결손중적작용작일종술，탐토기대인류방간격결손질병진단화치료적개치。
GATA6 transcription factor belongs to the GATA family and contains 2 conserved zinc ifnger DNA binding domains. GATA6 not only presents in embryonic tissues but also found in heart, lung and pancreas and is essential for the maintenance of their function.The present review focuses on the critical roles of GATA6 in heart development and atrial septal defect to provide theoretical basis for diagnosis and treatment of atrial septal defect.