CAJ | 학술논문

动脉粥样硬化是一种慢性的自身免疫性血管炎症疾病，不同的 T细胞亚群在其发生发展中发挥着不同的作用。T h17细胞亚群及其效应分子IL‐17主要发挥黏膜免疫防御和促进炎症作用，在多种慢性炎症疾病和自身免疫疾病中发挥重要作用。然而T h17／IL‐17在动脉粥样硬化中的作用尚无定论，各家研究结果存在明显的冲突。本文全面综述前人的研究成果，分析导致差异的原因。以期能为深入研究T h17／IL‐17在动脉粥样硬化中的作用提供有力参考。
동맥죽양경화시일충만성적자신면역성혈관염증질병，불동적 T세포아군재기발생발전중발휘착불동적작용。T h17세포아군급기효응분자IL‐17주요발휘점막면역방어화촉진염증작용，재다충만성염증질병화자신면역질병중발휘중요작용。연이T h17／IL‐17재동맥죽양경화중적작용상무정론，각가연구결과존재명현적충돌。본문전면종술전인적연구성과，분석도치차이적원인。이기능위심입연구T h17／IL‐17재동맥죽양경화중적작용제공유력삼고。
Atherosclerosis is a chronic autoimmune and inflmmatory arterial disease .Different subsets of T cells play distinct and opposing roles .Th17 cells and the prototype cytokine interleukin‐17 have been characterized and shown to be critical in mucosal host defense and several autoimmune and inflammatory diseases .However , studies in atherosclerosis led to conflcting results on the roles of interleukin‐17 and T helper‐17 cells .The present review provides a summary of the available evidences and the reasons for the conflcting results to provide a valua‐ble reference for the further research .