CAJ | 학술논문

目的：本研究旨在运用 C 反应蛋白（CRP）作为全身及肿瘤局部炎症反应的参数，分析其与新辅助化疗前后乳腺癌患者的临床病理生物学因素之间的关系及其对新辅助化疗疗效的影响。方法本研究回顾性分析了我院乳腺外科2001年1月至2010年6月确诊并接受新辅助化疗的Ⅱ－Ⅲ期乳腺癌患者共215例。按不同的病理完全缓解（pCR）标准分组（包括原发灶和淋巴结及仅包括原发灶），统计学分析 CRP 与新辅助化疗患者的临床病理特征及病理完全缓解（pCR）之间的关系。结果达到 pCR 的患者较非 pCR 患者的 CRP 均值更低（P＝0．035和 P＝0．032），CRP 对pCR（仅包括原发灶）有良好的预测价值（P＜0．001）。结论新辅助化疗前 CRP 水平有助于预测新辅助化疗疗效。
목적：본연구지재운용 C 반응단백（CRP）작위전신급종류국부염증반응적삼수，분석기여신보조화료전후유선암환자적림상병리생물학인소지간적관계급기대신보조화료료효적영향。방법본연구회고성분석료아원유선외과2001년1월지2010년6월학진병접수신보조화료적Ⅱ－Ⅲ기유선암환자공215례。안불동적병리완전완해（pCR）표준분조（포괄원발조화림파결급부포괄원발조），통계학분석 CRP 여신보조화료환자적림상병리특정급병리완전완해（pCR）지간적관계。결과체도 pCR 적환자교비 pCR 환자적 CRP 균치경저（P＝0．035화 P＝0．032），CRP 대pCR（부포괄원발조）유량호적예측개치（P＜0．001）。결론신보조화료전 CRP 수평유조우예측신보조화료료효。
Objective To analyze the relationship between C reactive protein (CRP) and clinical pathobiiology factors before and after neoadjuvant chemotherapy. Methods This research retrospectively analyzed 215 patients , who were diagnosed as breast cancer in stage Ⅱ-Ⅲ, admitted in the Breast Cancer Department of our hospital and accepted NAC in January 2001 to June 2010. The relationship of CRP with clinicopathological characteristics as well as efficacy of prediction of pathologic complete response according to two different standards were statistically analyzed. Results Patients with pCR were in lower CRP value comparing with non-pCR patients. CRP reached a high efficacy in predicting pCR (the absence of all invasive disease in the breast tumor ). Conclusion The protein level of CRP shows predictive value of pCR with neoadjuvantchemotherapy patients.