CAJ | 학술논문

目的：探讨恶性肿瘤患者乙型肝炎病毒（HBV）血清标志物（HBV－M）和HBV DNA检测结果及临床意义。方法采用化学发光免疫分析和荧光定量PCR方法，对所有病例及对照组进行HBV－M和HBV DNA检测。结果405例各种恶性肿瘤患者HBV－M阳性共185例，阳性率为45．7％，HBV DNA检出率大三阳组为100％（19／19），小三阳组为60．0％（15／25），二者比较具有显著性的统计学意义（P＜0．05）。肝癌患者的阳性率最高，达89．2％；其次为胃、食管、直肠癌，其阳性率分别为48．9％、45．5％、45．2％；白血病为35．8％；肺、鼻咽癌分别为32．4％、25．0％；（恶性）淋巴瘤、甲状腺癌、宫颈癌的阳性率分别为32．0％、28．8％、23．8％。与对照组比较，差异有统计学意义（P＜0．01），恶性消化道肿瘤患者HBV感染的阳性率与其他系统恶性肿瘤患者相比明显偏高（P＜0．05）。结论恶性肿瘤患者的HBV感染阳性率高，其中消化道恶性肿瘤的HBV感染阳性率最高。
목적：탐토악성종류환자을형간염병독（HBV）혈청표지물（HBV－M）화HBV DNA검측결과급림상의의。방법채용화학발광면역분석화형광정량PCR방법，대소유병례급대조조진행HBV－M화HBV DNA검측。결과405례각충악성종류환자HBV－M양성공185례，양성솔위45．7％，HBV DNA검출솔대삼양조위100％（19／19），소삼양조위60．0％（15／25），이자비교구유현저성적통계학의의（P＜0．05）。간암환자적양성솔최고，체89．2％；기차위위、식관、직장암，기양성솔분별위48．9％、45．5％、45．2％；백혈병위35．8％；폐、비인암분별위32．4％、25．0％；（악성）림파류、갑상선암、궁경암적양성솔분별위32．0％、28．8％、23．8％。여대조조비교，차이유통계학의의（P＜0．01），악성소화도종류환자HBV감염적양성솔여기타계통악성종류환자상비명현편고（P＜0．05）。결론악성종류환자적HBV감염양성솔고，기중소화도악성종류적HBV감염양성솔최고。
Objective To investigate hepatitis B virus (HBV) markers in the malignant tumor patients serum (HBV-M) and HBV DNA detection results and their clinical significance. Methods Chemiluminescence immunoassay and fluorescence quantitative PCR method were used in detection of the patients and control group in HBV-M and HBV DNA. Results In 405 patients with HBV-M positive,were 185 cases of malignant tumor, the positive rate was 45.7%;HBV DNA positive rate of HBeAg group was 100%(19/19);Small "Sanyang" group was 60%(15/25),Statistical significance among the two groups was significant (P<0.05). The positive rate of liver cancer patients was with the highest,up to 89.2%;Secondary,esophageal,gastric cancer,i.e positive rates were 48.9%,45.5%,45.2%;Leukemia was 35.8%; lung,nasopharyngeal carcinoma were 32.4%,25%;(malignant),the positive rate of lymphoma of thyroid cancer,cervical cancer were 32%,28.8%,23.8% respectively. Compared with the control group,the difference was statistically significant (P<0.01),malignant tumor of digestive tract in patients infected with HBV positive rate is significantly higher than patients with other malignant tumors (P<0.05). Conclusion HBV in patients with malignant tumor infection positive rate is high,the malignant tumor of digestive tract HBV infection positive rate is the highest.