中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2015年
4期
299-303
,共5页
周斌%李立明%吕筠%余灿清%王胜锋%逄增昌%丛黎明%董忠%吴凡
週斌%李立明%呂筠%餘燦清%王勝鋒%逄增昌%叢黎明%董忠%吳凡
주빈%리립명%려균%여찬청%왕성봉%방증창%총려명%동충%오범
双生子%体重指数%遗传度%成年人
雙生子%體重指數%遺傳度%成年人
쌍생자%체중지수%유전도%성년인
Twins%Body mass index%Heritability%Adult
目的 探讨中国9省(市)成年双生子BMI遗传度情况.方法 收集中国双生子登记系统9省(市)成年双生子信息,采用结构方程模型计算11 122对双生子BMI遗传度.结果 研究对象中同卵双生子6 226对,异卵双生子4 896对,年龄范围25 ~ 85(39.0±10.8)岁.按地区分层,男性BMI遗传度最高的是天津,为67.8%(95%CI:50.1% ~ 85.8%),最低的是浙江,为42.1%(95%CI:27.2%~60.9%);女性最高的是四川,为56.2%(95%CI:47.5% ~ 70.0%),最低的是黑龙江,为11.2%(95%CI:0~31.7%).按性别分层,相同地区的男性BMI遗传度均高于女性,其中黑龙江男性和女性的遗传度差异最大,分别为55.3%(95%CI:35.5% ~ 80.0%)和11.2%(95%CI:0~31.7%),而四川男性和女性的遗传度差异最小,分别为61.5%(95%CI:40.7%~86.4%)和56.2%(95%CI:47.5%~70.0%).结论 中国不同地区和不同性别人群BMI遗传度存在差别.
目的 探討中國9省(市)成年雙生子BMI遺傳度情況.方法 收集中國雙生子登記繫統9省(市)成年雙生子信息,採用結構方程模型計算11 122對雙生子BMI遺傳度.結果 研究對象中同卵雙生子6 226對,異卵雙生子4 896對,年齡範圍25 ~ 85(39.0±10.8)歲.按地區分層,男性BMI遺傳度最高的是天津,為67.8%(95%CI:50.1% ~ 85.8%),最低的是浙江,為42.1%(95%CI:27.2%~60.9%);女性最高的是四川,為56.2%(95%CI:47.5% ~ 70.0%),最低的是黑龍江,為11.2%(95%CI:0~31.7%).按性彆分層,相同地區的男性BMI遺傳度均高于女性,其中黑龍江男性和女性的遺傳度差異最大,分彆為55.3%(95%CI:35.5% ~ 80.0%)和11.2%(95%CI:0~31.7%),而四川男性和女性的遺傳度差異最小,分彆為61.5%(95%CI:40.7%~86.4%)和56.2%(95%CI:47.5%~70.0%).結論 中國不同地區和不同性彆人群BMI遺傳度存在差彆.
목적 탐토중국9성(시)성년쌍생자BMI유전도정황.방법 수집중국쌍생자등기계통9성(시)성년쌍생자신식,채용결구방정모형계산11 122대쌍생자BMI유전도.결과 연구대상중동란쌍생자6 226대,이란쌍생자4 896대,년령범위25 ~ 85(39.0±10.8)세.안지구분층,남성BMI유전도최고적시천진,위67.8%(95%CI:50.1% ~ 85.8%),최저적시절강,위42.1%(95%CI:27.2%~60.9%);녀성최고적시사천,위56.2%(95%CI:47.5% ~ 70.0%),최저적시흑룡강,위11.2%(95%CI:0~31.7%).안성별분층,상동지구적남성BMI유전도균고우녀성,기중흑룡강남성화녀성적유전도차이최대,분별위55.3%(95%CI:35.5% ~ 80.0%)화11.2%(95%CI:0~31.7%),이사천남성화녀성적유전도차이최소,분별위61.5%(95%CI:40.7%~86.4%)화56.2%(95%CI:47.5%~70.0%).결론 중국불동지구화불동성별인군BMI유전도존재차별.
Objective To explore the heritability of body mass index (BMI) in twins across different regions and genders in China.Methods A total of 11 122 adult twin pairs from the Chinese National Twin Registry were interviewed.A structural equation model was used to estimate the heritability of BMI.Results This study included 6 226 monozygotic twin pairs and 4 896 dizygotic twin pairs,with the age range as 25-85 (39.0± 1 0.8) years.Under stratified analysis by region,results showed that the highest and lowest rates on heritability of BMI in men were seen in Tianjin and Zhejiang,as 67.8% (95%CI:50.1%-85.8%) and 42.1% (95%CI:27.2%-60.9%),while in women were seen in Sichuan and Heilongjiang as 56.2% (95% CI:47.5%-70.0%) and 11.2% (95% CI:0.0%-31.7%),respectively.Results from the stratified analysis showed that,by gender,the heritability of BMI in men was higher than that in women from the same region.The biggest differences of heritability of BMI between men and women were seen in Heilongjiang as 55.3% (95%CI:35.5%-80.0%) and 11.2% (95%CI:0-31.7%),while the smallest differences were seen in Sichuan as 61.5% (95% CI:40.7%-86.4%) and 56.2% (95% CI:47.5%-70.0%),respectively.Conclusion The heritability of BMI across different regions and genders showed certain differences in the Chinese twins.