中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2015年
4期
393-398
,共6页
邹金国%马依彤%谢翔%杨毅宁%刘芬
鄒金國%馬依彤%謝翔%楊毅寧%劉芬
추금국%마의동%사상%양의저%류분
冠心病%CYP1A1基因%单核苷酸多态性
冠心病%CYP1A1基因%單覈苷痠多態性
관심병%CYP1A1기인%단핵감산다태성
Coronary artery disease%CYP1A1%Single nucleotide polymorphism
目的 探讨新疆地区维吾尔(维)族人群细胞色素氧化酶基因CYP1A1多态性与冠心病的关联性.方法 使用实时PCR对293例冠心病患者(病例组)和408名健康体检者(对照组)CYP1A1基因单核苷酸多态性(SNPs:rs4886605,rs12441817,rs4646422,rs1048943)进行基因型鉴定.结果 维族人群病例组和对照组rs4886605的基因型及等位基因分布的差异均有统计学意义(均P＜0.05).病例组rs4886605显性模型(CCvs.CT+TT)基因型频率明显低于对照组.调整混杂因素后logistic回归分析表明,维族人群rs4886605的CC基因型者患冠心病风险明显低于CT+TT基因型者(总体:OR=0.368,95％CI:0.185 ～ 0.530,P=0.018;男性:OR=0.350,95％CI:0.235 ～ 0.568,P=0.015).病例组和对照组rs12441817的基因型及等位基因分布差异均有统计学意义(均P＜0.05).病例组的rs12441817显性模型(TTvs.CT+ CC)基因型频率明显低于对照组.调整混杂因素后logistic回归分析表明,维族人群rs12441817的TT基因型者患冠心病风险明显低于CT+ CC基因型者(总体:OR=0.253,95％CI:0.231～ 0.546,P=0.016;男性:OR=0.241,95％CI:0.132～ 0.478,P=0.002).结论 新疆维族人群CYP1A1基因多态性rs4886605、rs12441817的2个位点与发生冠心病相关.rs4886605的CC基因型、rs12441817的TT基因型可能是该人群发生冠心病的保护因素.
目的 探討新疆地區維吾爾(維)族人群細胞色素氧化酶基因CYP1A1多態性與冠心病的關聯性.方法 使用實時PCR對293例冠心病患者(病例組)和408名健康體檢者(對照組)CYP1A1基因單覈苷痠多態性(SNPs:rs4886605,rs12441817,rs4646422,rs1048943)進行基因型鑒定.結果 維族人群病例組和對照組rs4886605的基因型及等位基因分佈的差異均有統計學意義(均P＜0.05).病例組rs4886605顯性模型(CCvs.CT+TT)基因型頻率明顯低于對照組.調整混雜因素後logistic迴歸分析錶明,維族人群rs4886605的CC基因型者患冠心病風險明顯低于CT+TT基因型者(總體:OR=0.368,95％CI:0.185 ～ 0.530,P=0.018;男性:OR=0.350,95％CI:0.235 ～ 0.568,P=0.015).病例組和對照組rs12441817的基因型及等位基因分佈差異均有統計學意義(均P＜0.05).病例組的rs12441817顯性模型(TTvs.CT+ CC)基因型頻率明顯低于對照組.調整混雜因素後logistic迴歸分析錶明,維族人群rs12441817的TT基因型者患冠心病風險明顯低于CT+ CC基因型者(總體:OR=0.253,95％CI:0.231～ 0.546,P=0.016;男性:OR=0.241,95％CI:0.132～ 0.478,P=0.002).結論 新疆維族人群CYP1A1基因多態性rs4886605、rs12441817的2箇位點與髮生冠心病相關.rs4886605的CC基因型、rs12441817的TT基因型可能是該人群髮生冠心病的保護因素.
목적 탐토신강지구유오이(유)족인군세포색소양화매기인CYP1A1다태성여관심병적관련성.방법 사용실시PCR대293례관심병환자(병례조)화408명건강체검자(대조조)CYP1A1기인단핵감산다태성(SNPs:rs4886605,rs12441817,rs4646422,rs1048943)진행기인형감정.결과 유족인군병례조화대조조rs4886605적기인형급등위기인분포적차이균유통계학의의(균P＜0.05).병례조rs4886605현성모형(CCvs.CT+TT)기인형빈솔명현저우대조조.조정혼잡인소후logistic회귀분석표명,유족인군rs4886605적CC기인형자환관심병풍험명현저우CT+TT기인형자(총체:OR=0.368,95％CI:0.185 ～ 0.530,P=0.018;남성:OR=0.350,95％CI:0.235 ～ 0.568,P=0.015).병례조화대조조rs12441817적기인형급등위기인분포차이균유통계학의의(균P＜0.05).병례조적rs12441817현성모형(TTvs.CT+ CC)기인형빈솔명현저우대조조.조정혼잡인소후logistic회귀분석표명,유족인군rs12441817적TT기인형자환관심병풍험명현저우CT+ CC기인형자(총체:OR=0.253,95％CI:0.231～ 0.546,P=0.016;남성:OR=0.241,95％CI:0.132～ 0.478,P=0.002).결론 신강유족인군CYP1A1기인다태성rs4886605、rs12441817적2개위점여발생관심병상관.rs4886605적CC기인형、rs12441817적TT기인형가능시해인군발생관심병적보호인소.
Objective To assess the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) among the Uygur population of China.Methods Genotypes of CYP1A1 single nucleotide polymorphisms (SNPs:rs4886605,rs 12441817,rs4646422 and rs1048943) were detected by real-time PCR in 293 CAD patients and 408 controls.Results Among the Uygur group,distribution of genotypes and allele of rs4886605 were both significantly different between CAD and the controls (all P＜0.05).The dominant model (CC vs.CT + TT) of rs4886605 was significantly lower among CAD patients than in controls.Significant differences were retained after the adjustment was made in all the participants (OR=0.368,95％CI:0.185-0.530,P=0.018) and in men (OR=0.350,95％CI:0.235-0.568,P=0.015).Distributions of genotypes and allele of rs12441817 were both significantly different between CAD and the controls (all P＜0.05).The dominant model (TT vs.CT+CC) of rs12441817 was significantly lower among patients CAD than in controls.Significant difference were retained after the adjustment was made,in total participants (OR=0.253,95％ CI:0.231-0.546,P=0.016) and in men (OR=0.241,95％ CI:0.132-0.478,P=0.002).Conclusion Both rs4886605 and rs12441817 SNPs of the CYP1A1 gene were associated with CAD in the Uygur population of China.
