CAJ | 학술논문

目的了解北京市肠道门诊腹泻患者诺如病毒感染的流行状况及临床特点.方法采集2013年4月至2014年3月北京市肠道门诊1 892名腹泻患者粪便标本,并收集患者的流行病学及临床症状资料.使用real time RT-PCR对诺如病毒核酸进行检测,采用描述性流行病学方法进行分析.结果 2013年4月至2014年3月北京市肠道门诊腹泻患者诺如病毒阳性率为14.2％(269/1 892);寒冷月份阳性率较高;怀柔区、延庆县等西北部山区阳性率较高;6月龄至5岁儿童诺如病毒阳性率高于其他年龄组,差异有统计学意义(P=0.006),散居托幼儿童诺如病毒阳性率高于其他职业人群,差异有统计学意义(P=0.025);诺如病毒阳性腹泻患者恶心、呕吐症状发生率高于阴性患者,差异有统计学意义(P＜0.05).结论诺如病毒是肠道门诊腹泻患者的重要病原,6月龄至5岁腹泻儿童诺如病毒感染率高于其他人群,恶心、呕吐为诺如病毒感染的常见症状.
목적 료해북경시장도문진복사환자낙여병독감염적류행상황급림상특점.방법 채집2013년4월지2014년3월북경시장도문진1 892명복사환자분편표본,병수집환자적류행병학급림상증상자료.사용real time RT-PCR대낙여병독핵산진행검측,채용묘술성류행병학방법진행분석.결과 2013년4월지2014년3월북경시장도문진복사환자낙여병독양성솔위14.2％(269/1 892);한랭월빈양성솔교고;부유구、연경현등서북부산구양성솔교고;6월령지5세인동낙여병독양성솔고우기타년령조,차이유통계학의의(P=0.006),산거탁유인동낙여병독양성솔고우기타직업인군,차이유통계학의의(P=0.025);낙여병독양성복사환자악심、구토증상발생솔고우음성환자,차이유통계학의의(P＜0.05).결론 낙여병독시장도문진복사환자적중요병원,6월령지5세복사인동낙여병독감염솔고우기타인군,악심、구토위낙여병독감염적상견증상.
Objective To investigate the epidemiological and clinical characteristics of norovirus infection on diarrhea patients from the enteric clinics in Beijing.Methods From April 2013 to March 2014,1 892 fecal specimens and related epidemiological information were collected among diarrhea patients visiting the enteric clinics in Beijing.Norovirus was detected by real time RT-PCR,and data was analyzed under the descriptive epidemiological method.Results A total of 269 positive cases were found among 1 892 diarrhea patients,with a positive rate as 14.2％.Norovirus caused diarrhea mainly occurred in seasons with lower temperature.Higher positive rates of norovirus were found in northwest mountainous area.Norovirus diarrhea was more commonly seen in children between 6 month and 5 years old,with differences between the two groups statistically significant (P=0.006).Compared with other occupation,a higher infection rate was identified in children,with differences between the two groups statistically significant (P=0.025).Nausea and vomiting appeared more common in diarrhea patients with norovirus infection,with differences between the two groups statistically significant (P＜0.05).Conclusion Norovirus was an important pathogen which causing diarrhea in patients visiting the enteric clinics in Beijing.The virus was seen more in patients aged between 6 months and 5 years old.Nausea and vomiting were the common symptoms seen in patients with norovirus diarrhea.