中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2015年
4期
379-382
,共4页
彭瑾瑜%陈曦%贺健梅%郑军%覃碧云%江洋
彭瑾瑜%陳晞%賀健梅%鄭軍%覃碧雲%江洋
팽근유%진희%하건매%정군%담벽운%강양
丙型肝炎病毒%人类免疫缺陷病毒%白细胞介素-28B%平衡性核苷转运载体1%自发清除%单核苷酸多态性
丙型肝炎病毒%人類免疫缺陷病毒%白細胞介素-28B%平衡性覈苷轉運載體1%自髮清除%單覈苷痠多態性
병형간염병독%인류면역결함병독%백세포개소-28B%평형성핵감전운재체1%자발청제%단핵감산다태성
Hepatitis C virus%Human immunodeficiency virus%Interleukin 28B%Equilibrative nucleoside transporters 1%Spontaneous clearance%Single nucleotide polymorphism
目的 分析湖南省HIV/HCV合并感染者的白细胞介素-28B (IL-28B)和平衡性核苷转运载体1 (ENTl)基因多态性与HCV自发清除的关系.方法 对湖南省107例HIV/HCV合并感染者的IL-28B和ENT1基因位点(rs12980275、rs12979860、rs8099917和rs760370)进行分型,比较其在慢性肝炎组和自发清除组的基因多态性分布.结果 在HIV/HCV合并感染者中,IL-28B基因rs12980275、rs12979860和rs8099917位点的主要基因型分别为AA、CC和TT型,均占84.1％.3个位点高度连锁不平衡(r2＞0.94),慢性肝炎组和自发清除组基因型分布差异有统计学意义(P＜0.05),携带IL-28B主要基因型的感染者更易发生HCV自发清除.ENT1基因的rs760370位点基因型分布在两组间的差异无统计学意义(P＞0.05).结论 IL-28B基因AA、CC和TT型与HCV自发清除有关.
目的 分析湖南省HIV/HCV閤併感染者的白細胞介素-28B (IL-28B)和平衡性覈苷轉運載體1 (ENTl)基因多態性與HCV自髮清除的關繫.方法 對湖南省107例HIV/HCV閤併感染者的IL-28B和ENT1基因位點(rs12980275、rs12979860、rs8099917和rs760370)進行分型,比較其在慢性肝炎組和自髮清除組的基因多態性分佈.結果 在HIV/HCV閤併感染者中,IL-28B基因rs12980275、rs12979860和rs8099917位點的主要基因型分彆為AA、CC和TT型,均佔84.1％.3箇位點高度連鎖不平衡(r2＞0.94),慢性肝炎組和自髮清除組基因型分佈差異有統計學意義(P＜0.05),攜帶IL-28B主要基因型的感染者更易髮生HCV自髮清除.ENT1基因的rs760370位點基因型分佈在兩組間的差異無統計學意義(P＞0.05).結論 IL-28B基因AA、CC和TT型與HCV自髮清除有關.
목적 분석호남성HIV/HCV합병감염자적백세포개소-28B (IL-28B)화평형성핵감전운재체1 (ENTl)기인다태성여HCV자발청제적관계.방법 대호남성107례HIV/HCV합병감염자적IL-28B화ENT1기인위점(rs12980275、rs12979860、rs8099917화rs760370)진행분형,비교기재만성간염조화자발청제조적기인다태성분포.결과 재HIV/HCV합병감염자중,IL-28B기인rs12980275、rs12979860화rs8099917위점적주요기인형분별위AA、CC화TT형,균점84.1％.3개위점고도련쇄불평형(r2＞0.94),만성간염조화자발청제조기인형분포차이유통계학의의(P＜0.05),휴대IL-28B주요기인형적감염자경역발생HCV자발청제.ENT1기인적rs760370위점기인형분포재량조간적차이무통계학의의(P＞0.05).결론 IL-28B기인AA、CC화TT형여HCV자발청제유관.
Objective To explore the association between interleukin 28B (IL-28B),equilibrative nucleoside transporters 1 (ENT1) gene polymorphisms and spontaneous clearance of HCV in HIV/HCV co-infectors in Hunan province.Methods Genotypes of IL-28B and ENT1 (rs12980275,rs12979860,rs8099917 and rs760370) were analyzed in 107 HIV/HCV co-infectors in Hunan province and the distributions of gene polymorphisms were compared between chronic hepatitis and spontaneous clearance groups.Results The major genotypes in rs12980275,rs12979860 and rs8099917 of IL-28B were AA,CC and TT in HIV/HCV co-infectors,which accounted for 84.1％ of each.The three single nucleotide polymorphisms were highly linkage disequilibrium (r2＞0.94) and the differences of genotype distribution were statistically significant between chronic hepatitis and the spontaneous clearance groups (P＜0.05).Infectors which carrying the major genotypes were more susceptible to spontaneous clearance of HCV.Differences of the genotype distributions in rs760370 of ENT1 were not statistically significant between the two groups.Conclusion Genotypes AA,CC and TT of IL-28B were related to spontaneous clearance of HCV in HIV/HCV co-infectors.
