中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
8期
1181-1183
,共3页
李穗华%胡楚璇%谭文惠%范翠苗%洗煜
李穗華%鬍楚璇%譚文惠%範翠苗%洗煜
리수화%호초선%담문혜%범취묘%세욱
精神分裂症%中西医结合%解郁开窍丸%疗效%安全性
精神分裂癥%中西醫結閤%解鬱開纖汍%療效%安全性
정신분렬증%중서의결합%해욱개규환%료효%안전성
Schizophrenia%Combine traditional Chinese and Western medicine%Jieyu Kaiqiao pill%Efficacy%Safety
目的：研究中西医结合疗法治疗精神分裂症的临床疗效及安全性。方法选择精神分裂症患者130例，采用随机数字表法分为观察组和对照组，各65例。对照组予以奋乃静等西药治疗，观察组在对照组治疗基础上加用解郁开窍丸治疗。比较两组临床疗效、PANSS评分及药物不良反应发生情况。结果观察组治疗总有效率为96．92％，明显高于对照组的72．31％；观察组治疗后PANSS评分为（42．68±6．11）分，对照组为（55．12±6．45）分，两组PANSS评分均较治疗前明显降低，观察组治疗后PANSS评分明显低于对照组，差异有统计学意义（t＝6．61，P＜0．05）；观察组不良反应发生率为10．77％，明显低于对照组的58．46％，差异有统计学意义（χ2＝32．66，P＜0．05）。结论解郁开窍丸联合西药用于治疗精神分裂症，可显著提高疾病治疗的临床疗效，降低药物不良反应发生率。
目的：研究中西醫結閤療法治療精神分裂癥的臨床療效及安全性。方法選擇精神分裂癥患者130例，採用隨機數字錶法分為觀察組和對照組，各65例。對照組予以奮迺靜等西藥治療，觀察組在對照組治療基礎上加用解鬱開纖汍治療。比較兩組臨床療效、PANSS評分及藥物不良反應髮生情況。結果觀察組治療總有效率為96．92％，明顯高于對照組的72．31％；觀察組治療後PANSS評分為（42．68±6．11）分，對照組為（55．12±6．45）分，兩組PANSS評分均較治療前明顯降低，觀察組治療後PANSS評分明顯低于對照組，差異有統計學意義（t＝6．61，P＜0．05）；觀察組不良反應髮生率為10．77％，明顯低于對照組的58．46％，差異有統計學意義（χ2＝32．66，P＜0．05）。結論解鬱開纖汍聯閤西藥用于治療精神分裂癥，可顯著提高疾病治療的臨床療效，降低藥物不良反應髮生率。
목적：연구중서의결합요법치료정신분렬증적림상료효급안전성。방법선택정신분렬증환자130례，채용수궤수자표법분위관찰조화대조조，각65례。대조조여이강내정등서약치료，관찰조재대조조치료기출상가용해욱개규환치료。비교량조림상료효、PANSS평분급약물불량반응발생정황。결과관찰조치료총유효솔위96．92％，명현고우대조조적72．31％；관찰조치료후PANSS평분위（42．68±6．11）분，대조조위（55．12±6．45）분，량조PANSS평분균교치료전명현강저，관찰조치료후PANSS평분명현저우대조조，차이유통계학의의（t＝6．61，P＜0．05）；관찰조불량반응발생솔위10．77％，명현저우대조조적58．46％，차이유통계학의의（χ2＝32．66，P＜0．05）。결론해욱개규환연합서약용우치료정신분렬증，가현저제고질병치료적림상료효，강저약물불량반응발생솔。
Objective To evaluate the clinical efficacy and safety of combined therapy of Chinese and West-ern medicine in the treatment of schizophrenia.Methods According to the digital table,130 patients with schizophre-nia were randomly divided into the observation group and control group,with 65 cases in each group.The control group was treated with perphenazine and other Western medicine treatment,the observation group was treated based on the control group with Jieyu Kaiqiao pill added,The clinical curative effect,PANSS score and adverse drug reaction of both groups were compared.Results In the observation group,the total effective rate was 96.92%,significantly high-er than that of the control group (72.31%);After treatment,PANSS score of observation group was (42.68 ±6.11), while it was (55.12 ±6.45)in control group.The PANSS scores of both groups were significantly lower than that before treatment,PANSS score of observation group was significantly lower than that of the control group,there was significant difference between groups(t=6.61,P<0.05);the incidence of adverse reaction of the observation group was 10.77%,significantly lower than the control group (58.46%);the difference was statistically significant (χ2 =32.66,P<0.05).Conclusion Jieyu Kaiqiao pill combined with Western medicine for the treatment of schizophre-nia can significantly improve the clinical efficacy,reduce the incidence of adverse drug reactions.
